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Clinical Approach to Medical Management of Type 2 Diabetes

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Relative risk reduction for<br />

metformin treatment (%)<br />

UKPDS 34: relative risk reduction with<br />

metformin vs conventional treatment<br />

0<br />

10<br />

20<br />

30<br />

40<br />

50<br />

-32<br />

**<br />

-42<br />

*<br />

-36<br />

*<br />

-39<br />

-41<br />

*<br />

* p < 0.05 ** p < 0.01<br />

N=1704<br />

patients<br />

Lancet 1998;352:854–65

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