Clinical Approach to Medical Management of Type 2 Diabetes
Clinical Approach to Medical Management of Type 2 Diabetes
Clinical Approach to Medical Management of Type 2 Diabetes
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Pioglitazone<br />
• Is not associated with an increased CV risk<br />
• Is associated with an increased risk <strong>of</strong> urinary bladder<br />
cancer<br />
– removed from the market in France, Germany<br />
recommended not <strong>to</strong> be started in new patients<br />
– FDA (August 2011): “Interim results…suggested that<br />
taking ACTOS longer than 12 months increased the<br />
relative risk <strong>of</strong> developing bladder cancer…by 40% which<br />
equates <strong>to</strong> an absolute increase <strong>of</strong> 3 cases in 10,000 (from<br />
approximately 7 in 10,000 [without ACTOS] <strong>to</strong><br />
approximately 10 in 10,000 [with ACTOS])”
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