Clinical Approach to Medical Management of Type 2 Diabetes
Clinical Approach to Medical Management of Type 2 Diabetes
Clinical Approach to Medical Management of Type 2 Diabetes
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Basic Characteristics <strong>of</strong> Glitazones<br />
• Enhance muscle and adipose tissue response <strong>to</strong><br />
insulin, modulate PPAR-γ recep<strong>to</strong>r<br />
• Depends upon presence <strong>of</strong> insulin, appear <strong>to</strong> have a<br />
more durable effect on the glycemic control<br />
compared with SU<br />
• Decrease HbA 1c ~ 1.0 %<br />
• Side effects: edema, CHF, weight gain, bone<br />
fractures