Clinical Approach to Medical Management of Type 2 Diabetes
Clinical Approach to Medical Management of Type 2 Diabetes
Clinical Approach to Medical Management of Type 2 Diabetes
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Benefit assessment <strong>of</strong> long-term blood<br />
glucose lowering <strong>to</strong> near-normal levels in<br />
patients with type 2 diabetes mellitus<br />
• Systematic review <strong>of</strong> seven<br />
RCT including 28,000<br />
patients with type 2 DM<br />
– ACCORD<br />
– ADVANCE<br />
– VADT<br />
– UKPDS<br />
– KUMAMOTO<br />
– UGDP<br />
– Van der Does<br />
• The primary outcome was<br />
all-cause mortality<br />
• Secondary outcomes were<br />
late complications (MI,<br />
stroke, ESRD, amputation,<br />
blindness, therapy-related<br />
fac<strong>to</strong>rs in terms <strong>of</strong> severe<br />
hypoglycemia and serious<br />
adverse advents)<br />
Institute for Quality and Efficiency in Health Care Report No. A05-07, 2011
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