2007 Annual Report - College of Pharmacy - The Ohio State University

C. Gutteridge, J. Vo, C. Tillett, J. Vigilante, J. Dettmer, S. Patterson, K. Werbovetz, J. Capers, D. Nichols, A.
Bhattacharjee, L. Gerena. Antileishmanial and antimalarial chalcones: synthesis, efficacy and cytotoxicity of
pyridinyl and naphthalenyl analogs, Medicinal Chemistry, 3: 115-119, 2007.
D. Delfín, A. Bhattacharjee, A. Yakovich, and K. Werbovetz. Activity of and initial mechanistic studies on a novel
antileishmanial agent identified through in silico pharmacophore development and database searching, Journal of
Medicinal Chemistry, 49: 4196-4207, 2006.
D. Wu, T. George, E. Hurh, K. Werbovetz, and J. Dalton. Pre-systemic metabolism prevents in vivo
antikinetoplastid activity of N1, N4-substituted 3,5-dinitro sulfanilamide, GB-II-150, Life Sciences, 79: 1081-
1093, 2006.
T. George, J. Johnsamuel, D. Delfin, A. Yakovich, M. Mukherjee, M. Phelps, J. Dalton, D. Sackett, M. Kaiser, R.
Brun, and K. Werbovetz. Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline
sulfonamides and benzamides, Bioorganic and Medicinal Chemistry, 14: 5699-5710, 2006.
A. Yakovich, F. Ragone, J. Alfonzo, D. Sackett, and K. Werbovetz. Leishmania tarentolae: Purification and
characterization of tubulin and its suitability for antileishmanial drug screening, Experimental Parasitology, 114:
289-296, 2006.
Chin, Y.-W.; Jones, W.P.; Riswan, S.; Chai, H.; Farnsworth, N.R.; Cordell, G.A.; Swanson, S.M.; Cassady, J.M.;
Kinghorn, A.D. Cytotoxic clerodane type diterpenes from the leaves of Premna tomentosa. Phytochemistry, 2006,
67, 1243-1248.
Balunas, M.J., W.P. Jones, Y.-W. Chin, Q. Mi, N.R. Farnsworth, D.D. Soejarto, G.A. Cordell, S.M. Swanson,
J.M. Pezzuto, H.-B. Chai, and A.D. Kinghorn. Relationships between inhibitory activity against a cancer cell line
panel, profiles of plant collected, and compound classes isolated, in an anticancer drug discovery project. Chem.
Biodivers., 2006, 3, 897-915.
Mi, Q., S. Kim, B. Y. Hwang, B.-N. Su, H. Chai, Z.H. Arbieva, A.D. Kinghorn, and S.M. Swanson. Silvestrol
regulates G2/M checkpoint genes independent of p53 activity. Anticancer Res., 2006, 26, 3349-3356.
Jang, D.S., B.-N. Su, A.D. Pawlus, Y.-H. Kang, S. Riswan, J.J. Afriastini, H.H.S. Fong, J.M. Pezzuto, and A.D.
Kinghorn. Beccaridiol, a 28-nortriterpenoid from the leaves of Diplectaria beccariana. Phytochemistry 2006, 67,
1832-1837.
Choi, J. K.; Murillo, G.; Su, B.-N.; Pezzuto, J.M.; Kinghorn, A.D.; Mehta, R.G. Ixocarpalactone A isolated from
the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells. FEBS J., 2006,
273, 5714-5723.
Chin, Y.-W.; Mdee, M.K.; Mbwambo, Z.H.; Mi, Q.; Chai, H,-B.; Cragg, G.M.; Swanson, S.M.; Kinghorn, A.D.
Prenylated flavonoids from the root bark of Berchemia discolor, a Tanzanian medicinal plant. J. Nat. Prod., 2006,
69, 1649-1652.
Kim, S.; Chin, Y.-W.; Su, B.-N.; Riswan, S.; Kardono, L.B.S.; Afriastini, J.J.; Chai, H.; Farnsworth, N.R.;
Cordell, G.A.; Swanson, S.M.; Kinghorn, A.D. Cytotoxic flavonoids and bisamides from Aglaia edulis. J. Nat.
Prod., 2006, 69, 1769-1775.
Salim, A.A.; Pawlus, A.D.; Chai, H.-B.; Farnsworth, N.R.; Kinghorn, A.D.; Carache-Blanco, E.J. Ponapensin, a
cyclopenta[b,c]benzopyran with potent NF-kB inhibitory activity from Aglaia ponapensis. Bioorg. Med. Chem.
Lett., 2007, 15, 109-112.
Jones, W.P.; Lobo-Echeverri, T.; Mi, Q.; Chai, H.-B.; Soejarto, D.D.; Cordell, G.A.; Swanson, S.M.; Kinghorn,
A.D. Cytotoxic constituents from the fruiting branches of Callicarpa mericana collected in southern Florida. J.
Nat. Prod., 2007, 70, 373-377. [Included in a special issue in honor of the late Dr. K.L. Rinehart (March, 2007)].
Salim, A.A., B.-N. Su, H.-B. Chai, S. Riswan, L.B.S. Kardono, A. Ruskandi, N.R. Farnsworth, S.M. Swanson,
and A.D. Kinghorn. Dioxadispiroketal compounds and potential acyclic precursor from Amomum aculeatum.
Tetrahedron Lett., 2007, 48, 1849-1853.
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