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What’s behind “cell mechanics” and why is it<br />

so important in biology<br />

Stiffness in Cell differentiation<br />

• Nature of <strong>the</strong> scaffold:<br />

(same stem cells)<br />

or<br />

1 kPa 0.1 kPa 0.01 kPa<br />

or<br />

or<br />

or<br />

different cell types<br />

• Tilt:<br />

(same stem cells and same substrate)<br />

or or or or<br />

0º 5º 10º<br />

different cell types<br />

• AFM and fluorescence micros<strong>copy</strong> can be used.<br />

1/22/2013 BRUKER CONFIDENTIAL<br />

3

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