Antibody Engineering Conference, San Diego - MorphoSys

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Screening for IgG1 Expression Levels VH1 VH3 VH4,5,6 kappa lambda Framework combinations are selected for human IgG1 expression levels and low expressing HCs are excluded (e.g., VH1_2, VH4_31). Page 14 2011 Antibody Engineering © MorphoSys AG
Combination of all Screening Parameters low Fab display low Fab expression level low Fab thermostability moderate hIgG1 expression high Fab display moderate Fab expression level high Fab thermostability high hIgG1 expression Selection of ~100 HC/LC pairs with favorable properties for research scale expression, purification and biophysical testing. Page 15 2011 Antibody Engineering © MorphoSys AG
Page 1 and 2: A New Antibody Library Concept (AB
Page 3 and 4: AGENDA 1. Features of Ylanthia 2. R
Page 5 and 6: Selection of Top 20 HC and 20 LC Ge
Page 7 and 8: Reduction of Potential Post-Transla
Page 9 and 10: Screening 400 HC/LC Pairs for Bioph
Page 11 and 12: Screening for Fab Phage Display Lev
Page 13: … Screening for IgG1 Expression L
Page 17 and 18: Ylanthia CDRs: Slonomics Inside Pag
Page 19 and 20: Ylanthia CDR-H3 Design � Lengths
Page 21 and 22: AGENDA 1. Features of Ylanthia 2. R
Page 23 and 24: Library QC by Next Generation Seque
Page 25 and 26: Library Features - Correctness �
Page 27 and 28: Antibody Selections - Snapshot* *be
Page 29 and 30: Biophysical Properties of Selected
Page 31 and 32: Biophysical Properties of Selected
Page 33: www.morphosys.com HuCAL Page 33 201

Antibody Engineering Conference, San Diego - MorphoSys

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