Antibody Engineering Conference, San Diego - MorphoSys
Antibody Engineering Conference, San Diego - MorphoSys
Antibody Engineering Conference, San Diego - MorphoSys
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Analyzing the Natural Human <strong>Antibody</strong><br />
Repertoire<br />
Ranking of most prominent<br />
variable region genes and<br />
VH/VL pairings:<br />
� Extraction of V gene usage and<br />
VH/VL pairing frequencies from<br />
own B-cell sequencing efforts and<br />
several publications analyzing<br />
both, autoimmune and healthy<br />
people*.<br />
� Analysis of VH/Vk as well as<br />
VH/Vλ pairings.<br />
Ranking according to natural<br />
occurrence.<br />
* Wardemann H. et al. Science (2003); Yurasov S. et al. JEM (2005); Tsuiji M. et al. JEM (2006); Yurasov S. et al. JEM (2006);<br />
Tiller T. et al. Immunity (2007); Mietzner B. PNAS (2008); Kofer J. et al: unpublished/ personal communication;<br />
Brezinschek H.P. et al. JCI (1997); Demaisson C. et al. Immunogenetics (1995); Foster S.J. at al. JCI (1997)<br />
VH<br />
Page 4 2011 <strong>Antibody</strong> <strong>Engineering</strong><br />
© <strong>MorphoSys</strong> AG<br />
V�
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