Antibody Engineering Conference, San Diego - MorphoSys
Antibody Engineering Conference, San Diego - MorphoSys
Antibody Engineering Conference, San Diego - MorphoSys
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Ylanthia: Distinct Heavy/Light Chain Pairing<br />
� Single framework libraries:<br />
HC/LC pair selected for biophysical properties;<br />
limited structural repertoire<br />
� Multiple framework synthetic and PCR-based<br />
libraries: High structural diversity; but random<br />
HC/LC pairing might yield to, e.g., antibody<br />
instability<br />
� Ylanthia: 36 distinct HC/LC pairs<br />
pre-selected for favorable biophysical<br />
properties<br />
� High structural diversity through main canonical<br />
CDR conformations of HC & LC<br />
� Only stable, well expressing HC/LC combinations<br />
Page 6 2011 <strong>Antibody</strong> <strong>Engineering</strong><br />
© <strong>MorphoSys</strong> AG
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