Issue-4_April - Asian Journal of Research in Chemistry (AJRC)

The in-vitro Bacteriostatic Potential of Some Traditionally used Indian Spices.
P. Kamleshiya 1 *, V.G. Meshram 1 , A.H. Ansari 2 ………………………………………………………………………….492
1 P.G. Department of Biochemistry, RTM Nagpur University LIT Campus Nagpur , India
2 Department of Biochemistry, S .K. Porwal College, Kamthee, Nagpur India
ABSTRACT:
The in-vitro antibacterial activity of aqueous and methanolic extract of some Indian spices, Cinnamom cassia,
Myristica fragrans, Murraya koenigii, Piper nigrum and Trachyspermum ammi against Bacillus Subtilis, Bacillus
Cereus, Escherichia Coli, Psuedomonas aeruginosa and Staphylococcus aureus was evaluated by using agar
diffusion assay and their antibacterial effect was compared with some standard antibiotics. The minimum inhibitory
concentration (MIC) of the extracts showing higher efficacy against the test organism was determined. By and large,
all the extract possessed antimicrobial property but comparatively the methanolic extracts are more potent than
aqueous extract of spices. MICs for aqueous and methanolic extracts ranged from 20-80 mg/ml and 5-20 mg/ml
respectively. The obtained results shows that spices have a natural bacteriostatic potential to be used as antimicrobial
agent.
KEYWORDS: Spice, Antibacterial activity, aqueous extract and methanolic extract.
Development and validation of UV Spectrophotometric method for quick estimation of milnacipran HCl in
dissolution media.
Nayan C. Ratnakar 1 *, K. N. Patel 2 , D. B. Doshi 3 …………………………………………………………………………497
1 Research Scholar, Singhania University, Jhunjhunu, Rajasthan.
2 SAL Institute of Pharmacy, Ahmedabad.Gujarat.
3 L. M. College of Pharmacy, Ahmedabad, Gujarat.
ABSTRACT:
A simple, sensitive, accurate, precise, reproducible, economic spectrophotometric method has been developed for
the estimation of milnacipran hydrochloride in dissolution medium. UV spectrophotometric method is based on
measurement of absorption at maximum wavelength 223 nm. The percentage recovery of milnacipran HCl ranged
from 99.82-101.23 %.in pharmaceutical dosage form. The developed method was validated with respect to linearity,
accuracy (recovery), precision (intra and interday variations). and specificity. Beers law was obeyed in the
concentration range of 2-40g/ml with correlation coefficient of 0.997. Results of the analysis were validated
statistically and by recovery study.
KEYWORDS: Milnacipran HCl; Spectrophotometric analysis; Validation; precision; accuracy; LOD; LOQ.
Studies of Thermal Conductivity in Carbon Nanotubes Using Simulation
Sunil H. Ganatra*, Sneha D. Khobragade, Anushree S. Ujjankar, Chudaman D. Pourkar……………………...500
Department of Chemistry, Institute of Science, R. T. Road, Nagpur – 440001, M.S. India
ABSTRACT:
The Nano Heat flow tool allows users to explore the time evolution of kinetic and potential energy among the
vibrational modes of a carbon nanotube over the course of a molecular dynamics (MD) simulation. It is possible to
observe the drop of vibrational energy through the modes of the system as a non-equilibrium population of phonons
is dissipated towards thermal equilibrium, and thus gives insight into the basic sources of damping and dissipation
within nanoscale objects.
Molecular Dynamics Simulation for Heat Flow in C(6,0), C(6,3) and C(6,6) carbon nanotubes were studied at
289.15 K using high performance parallel processing computers.
It is reported that the selected nanotubes i.e. C(6,0), C(6,3) and C(6,6) shows the thermal conductivity at various
frequencies.
The surprise results for C(6,0) and C(6,6) where the frequency is highly selective and give single peak. Whereas, in
case of C(6,3) various frequency peaks are reported and spread in wide spectrum.