Issue-4_April - Asian Journal of Research in Chemistry (AJRC)

KEYWORDS: Carbon nanotubes, Heat Flow, Thermal conductivity, Molecular dynamics.
Salicylaldehyde Schiff bases bioactivity prediction by Insilico approach
Valli G., Ramu K., Mareeswari P. …………………………………………………………………………………………..504
Department of Chemistry, SFR College for women, Sivakasi.
ABSTRACT:
Our study focuses the prediction of the bioactivity of Salicylaldehyde Schiff bases by computational method using
PASS (online software for bioactivity prediction) by knowing the importance of Schiff bases derived from
salicylaldehyde with various amines. Thirteen Schiff bases selected for our work. PASS prediction result showed
that salicylaldehyde o-phenylenediamine Schiff bases possessed higher laccase inhibitor (91.6% )activity and 3-
hydroxybenzoate 4-monooxygenase inhibitor(88%) activities. salicylaldehyde luicine Schiff base possessed
antiseborrheic(86.1%), Pro-opio melanocortin converting enzyme inhibitor(86.5%) and protein-glutamate methyl
esterase activity(85.2%). salicylaldehyde Schiff bases derived from 2-aminopyridine, ethylenediamine, Glycine, 2,4-
dinitrophenylhydrazine, 4-aminobenzene sulphonamide and methionine were found to have Glutathione
thiolesterase inhibitor(86.3%), Glucose oxidase inhibitor (86.1%), Monophenol monooxygenase inhibitor (86.5%) ,
Cis-1,2-dihydro-1,2dihydroxy naphthalene dehydrogenase inhibitor (89.5%),Anthranilate 3-monooxygenase
(deaminating)Inhibitor(88.7%) ,Corticosteroid side-chain-isomerase inhibitor (88.7%), Sulfite reductase
inhibitor(86.1%), Pullulanase inhibitor (85.8%) and 3-Phytase inhibitor(85.4%). Aryl acetonitrilase inhibitor
(85.2%), Arylformamidase inhibitor (91.2%), Phenylalanine (histidine) transaminase inhibitor (89.4%) and L-3-
cyanoalanine synthase inhibitor (88.9%) activities. They also found to act as Dopamine D4 agonist (89.5%) and
Antiprotozoal (Toxoplasma) (87%) compared to other Schiff bases.
KEYWORDS: o-phenylenediamine, Luicine, Laccase , salicylaldehyde, PASS.
HPTLC Method for the Simultaneous Estimation of Amlodipine Besylate and Indapamide in Tablet
Formulation
A.K. Desai*, R.S. Chauhan, S.A. Shah, D.R. Shah………………………………………………………………………..510
Maliba Pharmacy College, Bardoli, Gujarat, India -394350.
ABSTRACT:
A simple, precise and accurate high performance thin layer chromatographic method was developed and validated
for the simultaneous estimation of amlodipine besylate and indapamide in combined tablet dosage form. Pre-coated
silica gel 60F254 aluminium plate was selected as the stationary phase and dichloromethane: methanol: ammonia
8.5: 1.5: 0.1 (v/v/v) was used as developing mobile phase. The detection of amlodipine and indapamide was carried
out at 241nm. The method was validated for linearity, accuracy, precision, limit of detection and limit of
quantitation parameters. The correlation coefficient of amlodipine and indapamide were found to be 0.9995 and
0.9977 respectively. The average percentage recovery of amlodipine and indapamide were 98.49 -102.05 and 99.2 -
102.01 respectively. The proposed HPTLC method has potential applications for determination of amlodipine
besylate and indapamide in combined tablet dosage form.
KEYWORDS: HPTLC method, amlodipine, indapamide, method development, validation.
Validated RP-HPLC Method for Estimation of Rasagiline in Tablet Dosage Form
Bhavin Vaishnani, Ritu Kimbahune, Prachi Kabra*, Sanjay Surani, L.V.G. Nargund…………………………….515
Department of Quality Assurance, Nargund College of Pharmacy, Dattatreyanagar, II Main,100 Ft Ring Road, BSK
III Stage, Bangalore- 560 085, India.
ABSTRACT:
In the present study, a reverse phase high performance liquid chromatographic method was developed and validated
for the determination of Rasagiline in tablet dosage form with the use of Caffeine as an internal standard.