Issue-4_April - Asian Journal of Research in Chemistry (AJRC)

ABSTRACT:
A number of iron metal complexes of type [FeL 4 (H 2 O) 2 ]SO 4 where L=hetero cyclic nitrogen donor ligands
(imidazole, pyridine, piperadine piperazine, indole, benzimidazole, benzotriazole, triazole, quinoline, iso-quinoline,
carbazole) have been synthesized and characterized. These complexes are soluble in ordinary organic solvent. The
conductivity data shows that these complexes are 1:1 electrolytic in nature. The IR spectra reveal the coordination of
nitrogen of the ligand to central iron metal atom. The mass spectra for benzimidazole complex shows the molecular
ion peak at 660 and base peak at 119. The thermal decomposition studies indicate the presence of water molecule
which is associated to central metal ion. The loss of water molecule and decomposition of sulphate ion occurs at
250 0 c. Then after 100 0 c imidazole molecule is removed one by one, giving the Fe 3 O 4 as the final product.
KEYWORDS: Metal, complexes, ligands, indole, benzimidazole, triazole, IRspectra, mass spectra.
Design, Synthesis and Characterization of Some Novel Amino and Aldehyde Substituted Azaphenothiazines
Dhiraj Raghuvanshi 1 *, Pramod Kumar Sharma 1 , Nimita Manocha 1 , Shikha Agrawal 2 , Prerna
Chaturvedi 1 ……………………………………………………………………………………………………………………….532
1 Department of Pharmaceutical Chemistry, Swami Vivekanand College of Pharmacy, Near Toll Naka, Khandwa Road,
Indore, M.P. PIN-452020
2 Department of Pharmaceutics, Swami Vivekanand College of Pharmacy, Near Toll Naka, Khandwa Road, Indore, M.P.
PIN-452020
ABSTRACT:
Some novel series of amino and aldehyde substituted azaphenothiazines were synthesized by condensation of 2-
chloro-1-(10H-azaphenothiazin-10yl)ethanone with various amines and aryl aldehydes. As it is known that
substituted aldehyde and amine when attached with some alkyl chain or heterocyclic moiety can lead to potentially
biological active compound. The structure modification for their better biological activity includes substitution on
nitrogen at 10th position coupled with aliphatic/aromatic amine and aromatic aldehydes. The above result
established the fact that azaphenothiazine can be a rich source of biologically active compounds. The synthesized
compounds were confirmed with IR, 1HNMR and Mass spectroscopy. The bioavailability of compounds was
determined by Lipinski rule of 5 using customized software.
KEYWORDS: Azaphenothiazine, Bioavailability, Synthesis, Amino, Aryl, Mobile phase.
Ion-Pair Spectrophotometric Estimation of Ciprofloxacin in bulk and pharmaceutical formulations
A. S. Grewal 1* , S. K. Patro 2 , S. K. Kanungo 2 ……………………………………………………………………………..537
1 Jan Nayak Ch. Devi Lal Memorial College of Pharmacy, Sirsa 125055, Haryana, India
2 Institute of Pharmacy and Technology, Salipur, Cuttack 754202, Orissa, India
ABSTRACT:
The main objective was to develop and validate asimple, accurate, precise and sensitive ion-pair spectrophotometric
extraction method for the assay of Ciprofloxacin (CFX) in pure drug and tablets. The method is based upon the
reaction of Ciprofloxacin with methyl orange, forming a yellow colour complex in acidic medium, which is
extracted in chloroform and analyzed. The extracted complexes showed absorbance maxima (max) found to be at
429 nm. Beer's law was obeyed for a wide concentration range i.e.100-700 g/mLas the extracted species seemed
well defined and stable.Surface or an interphase adsorption phenomenon was not a problem. Optimization of the
reaction was carried out with factors such as buffer strength, stability of complex, molar ratio of drug: dye and
extraction time.The proposed method was validated as per ICH guidelines Q 2. The recovery studies confirmed the
accuracy and precision of the method. The above method was a rapid tool for routine analysis of Ciprofloxacin in
the bulk and pharmaceutical dosage forms.
KEYWORDS: Antibiotic; Ciprofloxacin determination; spectrophotometry; ion pair extraction; fluoroquinolone
Removal of Chromium (III) from drinking water using ash of bark of Terminalia arjuna