Chromatographic separation was carried out on a RP-18 column us<strong>in</strong>g a mobile phase consist<strong>in</strong>g <strong>of</strong> acetonitrile: isopropyl alcohol: water (10:20:70, v/v/v) adjusted at pH 2.5 with o-phosphoric acid (1%). The flow rate was ma<strong>in</strong>ta<strong>in</strong>ed at 0.8 ml m<strong>in</strong>−1 and UV detection was measured at 210 nm. The calibration curve was l<strong>in</strong>ear over the range 1-200µgml−1. R.S.D. for precision was
ABSTRACT: A number <strong>of</strong> iron metal complexes <strong>of</strong> type [FeL 4 (H 2 O) 2 ]SO 4 where L=hetero cyclic nitrogen donor ligands (imidazole, pyrid<strong>in</strong>e, piperad<strong>in</strong>e piperaz<strong>in</strong>e, <strong>in</strong>dole, benzimidazole, benzotriazole, triazole, qu<strong>in</strong>ol<strong>in</strong>e, iso-qu<strong>in</strong>ol<strong>in</strong>e, carbazole) have been synthesized and characterized. These complexes are soluble <strong>in</strong> ord<strong>in</strong>ary organic solvent. The conductivity data shows that these complexes are 1:1 electrolytic <strong>in</strong> nature. The IR spectra reveal the coord<strong>in</strong>ation <strong>of</strong> nitrogen <strong>of</strong> the ligand to central iron metal atom. The mass spectra for benzimidazole complex shows the molecular ion peak at 660 and base peak at 119. The thermal decomposition studies <strong>in</strong>dicate the presence <strong>of</strong> water molecule which is associated to central metal ion. The loss <strong>of</strong> water molecule and decomposition <strong>of</strong> sulphate ion occurs at 250 0 c. Then after 100 0 c imidazole molecule is removed one by one, giv<strong>in</strong>g the Fe 3 O 4 as the f<strong>in</strong>al product. KEYWORDS: Metal, complexes, ligands, <strong>in</strong>dole, benzimidazole, triazole, IRspectra, mass spectra. Design, Synthesis and Characterization <strong>of</strong> Some Novel Am<strong>in</strong>o and Aldehyde Substituted Azaphenothiaz<strong>in</strong>es Dhiraj Raghuvanshi 1 *, Pramod Kumar Sharma 1 , Nimita Manocha 1 , Shikha Agrawal 2 , Prerna Chaturvedi 1 ……………………………………………………………………………………………………………………….532 1 Department <strong>of</strong> Pharmaceutical <strong>Chemistry</strong>, Swami Vivekanand College <strong>of</strong> Pharmacy, Near Toll Naka, Khandwa Road, Indore, M.P. PIN-452020 2 Department <strong>of</strong> Pharmaceutics, Swami Vivekanand College <strong>of</strong> Pharmacy, Near Toll Naka, Khandwa Road, Indore, M.P. PIN-452020 ABSTRACT: Some novel series <strong>of</strong> am<strong>in</strong>o and aldehyde substituted azaphenothiaz<strong>in</strong>es were synthesized by condensation <strong>of</strong> 2- chloro-1-(10H-azaphenothiaz<strong>in</strong>-10yl)ethanone with various am<strong>in</strong>es and aryl aldehydes. As it is known that substituted aldehyde and am<strong>in</strong>e when attached with some alkyl cha<strong>in</strong> or heterocyclic moiety can lead to potentially biological active compound. The structure modification for their better biological activity <strong>in</strong>cludes substitution on nitrogen at 10th position coupled with aliphatic/aromatic am<strong>in</strong>e and aromatic aldehydes. The above result established the fact that azaphenothiaz<strong>in</strong>e can be a rich source <strong>of</strong> biologically active compounds. The synthesized compounds were confirmed with IR, 1HNMR and Mass spectroscopy. The bioavailability <strong>of</strong> compounds was determ<strong>in</strong>ed by Lip<strong>in</strong>ski rule <strong>of</strong> 5 us<strong>in</strong>g customized s<strong>of</strong>tware. KEYWORDS: Azaphenothiaz<strong>in</strong>e, Bioavailability, Synthesis, Am<strong>in</strong>o, Aryl, Mobile phase. Ion-Pair Spectrophotometric Estimation <strong>of</strong> Cipr<strong>of</strong>loxac<strong>in</strong> <strong>in</strong> bulk and pharmaceutical formulations A. S. Grewal 1* , S. K. Patro 2 , S. K. Kanungo 2 ……………………………………………………………………………..537 1 Jan Nayak Ch. Devi Lal Memorial College <strong>of</strong> Pharmacy, Sirsa 125055, Haryana, India 2 Institute <strong>of</strong> Pharmacy and Technology, Salipur, Cuttack 754202, Orissa, India ABSTRACT: The ma<strong>in</strong> objective was to develop and validate asimple, accurate, precise and sensitive ion-pair spectrophotometric extraction method for the assay <strong>of</strong> Cipr<strong>of</strong>loxac<strong>in</strong> (CFX) <strong>in</strong> pure drug and tablets. The method is based upon the reaction <strong>of</strong> Cipr<strong>of</strong>loxac<strong>in</strong> with methyl orange, form<strong>in</strong>g a yellow colour complex <strong>in</strong> acidic medium, which is extracted <strong>in</strong> chlor<strong>of</strong>orm and analyzed. The extracted complexes showed absorbance maxima (max) found to be at 429 nm. Beer's law was obeyed for a wide concentration range i.e.100-700 g/mLas the extracted species seemed well def<strong>in</strong>ed and stable.Surface or an <strong>in</strong>terphase adsorption phenomenon was not a problem. Optimization <strong>of</strong> the reaction was carried out with factors such as buffer strength, stability <strong>of</strong> complex, molar ratio <strong>of</strong> drug: dye and extraction time.The proposed method was validated as per ICH guidel<strong>in</strong>es Q 2. The recovery studies confirmed the accuracy and precision <strong>of</strong> the method. The above method was a rapid tool for rout<strong>in</strong>e analysis <strong>of</strong> Cipr<strong>of</strong>loxac<strong>in</strong> <strong>in</strong> the bulk and pharmaceutical dosage forms. KEYWORDS: Antibiotic; Cipr<strong>of</strong>loxac<strong>in</strong> determ<strong>in</strong>ation; spectrophotometry; ion pair extraction; fluoroqu<strong>in</strong>olone Removal <strong>of</strong> Chromium (III) from dr<strong>in</strong>k<strong>in</strong>g water us<strong>in</strong>g ash <strong>of</strong> bark <strong>of</strong> Term<strong>in</strong>alia arjuna
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