Revealing the Mechanism of HSP104 Transcription Initiation in the ...

More documents

Recommendations

Info

71. Kuras, L., P. Kosa, M. Mencia, and K. Struhl. 2000. TAF-Containing and TAF-independent forms of transcriptionally active TBP in vivo. Science 288:1244-8. 72. Kuras, L., and K. Struhl. 1999. Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme. Nature 399:609-13. 73. Kurdistani, S. K., and M. Grunstein. 2003. Histone acetylation and deacetylation in yeast. Nat Rev Mol Cell Biol 4:276-84. 74. Lallet, S., H. Garreau, C. Garmendia-Torres, D. Szestakowska, E. Boy- Marcotte, S. Quevillon-Cheruel, and M. Jacquet. 2006. Role of Gal11, a component of the RNA polymerase II mediator in stress-induced hyperphosphorylation of Msn2 in Saccharomyces cerevisiae. Mol Microbiol 62:438-52. 75. Lallet, S., H. Garreau, C. Poisier, E. Boy-Marcotte, and M. Jacquet. 2004. Heat shock-induced degradation of Msn2p, a Saccharomyces cerevisiae transcription factor, occurs in the nucleus. Mol Genet Genomics 272:353-62. 76. Lee, J., A. Romeo, and D. J. Kosman. 1996. Transcriptional remodeling and G1 arrest in dioxygen stress in Saccharomyces cerevisiae. J Biol Chem 271:24885-93. 77. Lee, S., T. Carlson, N. Christian, K. Lea, J. Kedzie, J. P. Reilly, and J. J. Bonner. 2000. The yeast heat shock transcription factor changes conformation in response to superoxide and temperature. Mol Biol Cell 11:1753-64. 78. Lemon, B., and R. Tjian. 2000. Orchestrated response: a symphony of transcription factors for gene control. Genes Dev 14:2551-69. 79. Li, B., M. Carey, and J. L. Workman. 2007. The role of chromatin during transcription. Cell 128:707-19. 80. Li, X. Y., A. Virbasius, X. Zhu, and M. R. Green. 1999. Enhancement of TBP binding by activators and general transcription factors. Nature 399:605-9. 81. Lindquist, S. 1986. The heat-shock response. Annu Rev Biochem 55:1151-91. 82. Lindquist, S., and E. A. Craig. 1988. The heat-shock proteins. Annu Rev Genet 22:631-77. 83. Liu, X. D., and D. J. Thiele. 1996. Oxidative stress induced heat shock factor phosphorylation and HSF-dependent activation of yeast metallothionein gene transcription. Genes Dev 10:592-603. 84. Lucchini, G., A. G. Hinnebusch, C. Chen, and G. R. Fink. 1984. Positive regulatory interactions of the HIS4 gene of Saccharomyces cerevisiae. Mol Cell Biol 4:1326-33. 85. Mager, W. H., and A. J. De Kruijff. 1995. Stress-induced transcriptional activation. Microbiol Rev 59:506-31. 86. Marchler, G., C. Schuller, G. Adam, and H. Ruis. 1993. A Saccharomyces cerevisiae UAS element controlled by protein kinase A activates transcription in response to a variety of stress conditions. Embo J 12:1997-2003. 87. Martinez-Pastor, M. T., G. Marchler, C. Schuller, A. Marchler-Bauer, H. Ruis, and F. Estruch. 1996. The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE). Embo J 15:2227-35. 88. Minehart, P. L., and B. Magasanik. 1991. Sequence and expression of GLN3, a positive nitrogen regulatory gene of Saccharomyces cerevisiae encoding a protein with a putative zinc finger DNA-binding domain. Mol Cell Biol 11:6216-28. 57
89. Miyao, T., J. D. Barnett, and N. A. Woychik. 2001. Deletion of the RNA polymerase subunit RPB4 acts as a global, not stress-specific, shut-off switch for RNA polymerase II transcription at high temperatures. J Biol Chem 276:46408-13. 90. Morimoto, R. I. 1998. Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev 12:3788-96. 91. Moskvina, E., C. Schuller, C. T. Maurer, W. H. Mager, and H. Ruis. 1998. A search in the genome of Saccharomyces cerevisiae for genes regulated via stress response elements. Yeast 14:1041-50. 92. Moye-Rowley, W. S., K. D. Harshman, and C. S. Parker. 1989. Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins. Genes Dev 3:283-92. 93. Neely, K. E., A. H. Hassan, C. E. Brown, L. Howe, and J. L. Workman. 2002. Transcription activator interactions with multiple SWI/SNF subunits. Mol Cell Biol 22:1615-25. 94. Ozaki, M., S. S. Deshpande, P. Angkeow, S. Suzuki, and K. Irani. 2000. Rac1 regulates stress-induced, redox-dependent heat shock factor activation. J Biol Chem 275:35377-83. 95. Park, J. M., J. Werner, J. M. Kim, J. T. Lis, and Y. J. Kim. 2001. Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock. Mol Cell 8:9-19. 96. Pedruzzi, I., N. Burckert, P. Egger, and C. De Virgilio. 2000. Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1. Embo J 19:2569-79. 97. Pillai, B., V. Sampath, N. Sharma, and P. Sadhale. 2001. Rpb4, a non-essential subunit of core RNA polymerase II of Saccharomyces cerevisiae is important for activated transcription of a subset of genes. J Biol Chem 276:30641-7. 98. Pillai, B., J. Verma, A. Abraham, P. Francis, Y. Kumar, U. Tatu, S. K. Brahmachari, and P. P. Sadhale. 2003. Whole genome expression profiles of yeast RNA polymerase II core subunit, Rpb4, in stress and nonstress conditions. J Biol Chem 278:3339-46. 99. Pirkkala, L., P. Nykanen, and L. Sistonen. 2001. Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. Faseb J 15:1118-31. 100. Pnueli, L., I. Edry, M. Cohen, and Y. Kassir. 2004. Glucose and nitrogen regulate the switch from histone deacetylation to acetylation for expression of early meiosis-specific genes in budding yeast. Mol Cell Biol 24:5197-208. 101. Raboy, B., A. Marom, Y. Dor, and R. G. Kulka. 1999. Heat-induced cell cycle arrest of Saccharomyces cerevisiae: involvement of the RAD6/UBC2 and WSC2 genes in its reversal. Mol Microbiol 32:729-39. 102. Rep, M., M. Krantz, J. M. Thevelein, and S. Hohmann. 2000. The transcriptional response of Saccharomyces cerevisiae to osmotic shock. Hot1p and Msn2p/Msn4p are required for the induction of subsets of high osmolarity glycerol pathway-dependent genes. J Biol Chem 275:8290-300. 103. Robert, F., D. K. Pokholok, N. M. Hannett, N. J. Rinaldi, M. Chandy, A. Rolfe, J. L. Workman, D. K. Gifford, and R. A. Young. 2004. Global position and recruitment of HATs and HDACs in the yeast genome. Mol Cell 16:199- 209. 58
Page 1 and 2:
Revealing the Mechanism of HSP104 T
Page 3 and 4:
This thesis is dedicated to my fami
Page 5 and 6:
genetic approach, we identified com
Page 7 and 8:
INTRODUCTION The cellular stress re
Page 9 and 10:
for their transcription, some 16% o
Page 11 and 12: Transcription under stress in S.cer
Page 13 and 14: In mammalian cells, Hsf1 is a monom
Page 15 and 16: Hsf1 and Msn2/4 can exclusively or
Page 17 and 18: A) 5’-XhoI -713 BamHI-3’ ATG La
Page 19 and 20: 1 We first noticed that the activit
Page 21 and 22: 1 1 A) B) 700 600 500 ras2∆msn2
Page 23 and 24: Table 1. Summary of the role of var
Page 25 and 26: same enzymes. BS-HA-HSF was obtaine
Page 27 and 28: β-Galactosidase assay Overnight cu
Page 29 and 30: to the fact that the HSEs are prese
Page 31 and 32: The systematic 5’ deletion analys
Page 33 and 34: 1 A) units 100.00 90.00 80.00 70.00
Page 35 and 36: nucleosome disassembly involving sp
Page 37 and 38: A) Strain W.T. msn2∆msn4∆ ras2
Page 39 and 40: Hsf1 constitutively binds the HSP10
Page 41 and 42: Next, we attempted to directly meas
Page 43 and 44: Table 3. List of mutants in which r
Page 45 and 46: Table 4. Strains required for posit
Page 47 and 48: Overall, the results nevertheless s
Page 49 and 50: Regulation of Hsf1 As explained in
Page 51 and 52: Table 7. Comparison between HSE-Lac
Page 53 and 54: promoter. III) The identification o
Page 55 and 56: to stress. This change in nucleosom
Page 57 and 58: perhaps not surprisingly, overexpre
Page 59 and 60: 21. Chandy, M., J. L. Gutierrez, P.
Page 61: 56. Hietakangas, V., J. K. Ahlskog,
Page 65 and 66: 121. Stanhill, A., N. Schick, and D
show all

Revealing the Mechanism of HSP104 Transcription Initiation in the ...

Create successful ePaper yourself

Delete template?

Save as template?