Paterson Institute for Cancer Research SCIENTIFIC REPORT 2005

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Cancer Research UK Paterson Institute for Cancer Research Scientific Report 2005 Edited by Professor Jenny Varley, Assistant Director (Research) Paterson Institute for Cancer Research Wilmslow Road, Manchester M20 4BX Tel: 0161 446 3156 http://www.paterson.man.ac.uk ISSN 1740-4525 Copyright © 2006 Cancer Research UK Printed by Cambrian Printers Cancer Research UK Registered Charity No. 1089464 Registered as a company limited by guarantee in England and Wales No. 4325234 Registered address 61 Lincoln’s Inn Fields, London WC2A 3PX Tel +44 (0) 20 7242 0200 http://www.cancerresearchuk.org
5 Contents Director’s Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Research Laboratories Bioinformatics Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Crispin Miller..................................................................8 Carcinogenesis Group. . . . . . . . . . . . . . . . . . . . . . . . . . . . . Geoff Margison..........................................................10 Cell Cycle Group. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Karim Labib..................................................................12 Cell Division Group. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Iain Hagan .....................................................................14 Cell Regulation Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . Nic Jones .......................................................................16 Cell Signalling Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Angeliki Malliri ............................................................18 Cellular and Molecular Pharmacology Group . . . . . . . . . Caroline Dive..............................................................20 Clinical and Experimental Pharmacology Group . . . . . . . Caroline Dive and Malcolm Ranson .............22 Gene Therapy Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Lez Fairbairn ................................................................24 Immunology Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Peter L Stern...............................................................26 Mitotic Spindle Function and Cell Cycle Control Group Elmar Schiebel............................................................28 Radiochemical Targeting and Imaging Group . . . . . . . . . . Jamal Zweit ..................................................................30 Stem Cell Biology Group . . . . . . . . . . . . . . . . . . . . . . . . . . Georges Lacaud ........................................................32 Stem Cell and Haematopoiesis Group. . . . . . . . . . . . . . . Valerie Kouskoff.........................................................34 Structural Cell Biology Group . . . . . . . . . . . . . . . . . . . . . . Terence D. Allen........................................................36 University of Manchester Division of Cancer Studies Academic Radiation Oncology Translational Radiogenomics Group. . . . . . . . . . . . . . . . . . . . . . . . . . . . . Catharine West..........................................................38 Medical Oncology: Breast Biology Group. . . . . . . . . . . . . Rob Clarke...................................................................40 Medical Oncology: Gene Immunotherapy Group . . . . . . Robert Hawkins ........................................................42 Medical Oncology: Glycoangiogenesis Group . . . . . . . . . Gordon Jayson ...........................................................44 Medical Oncology: Proteoglycan Group . . . . . . . . . . . . . . John T Gallagher........................................................46 Targeted Therapy Group. . . . . . . . . . . . . . . . . . . . . . . . . . . Tim Illidge......................................................................48 Research Services . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50 Publications. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56 Postgraduate Education . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68 Administrative Services . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70 Acknowledgement for Funding of the Paterson Institute. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72 Career Opportunities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74 How to Find Us . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . inside back cover P A T E R S O N I N S T I T U T E S C I E N T I F I C R E P O R T 2 0 0 5
Page 1 and 2: Paterson Institute for Cancer Resea
Page 3: Cancer Research UK Paterson Institu
Page 7 and 8: espect with his peers. He enjoyed l
Page 9 and 10: BIOINFORMATICS age, MIAME VICE is b
Page 11 and 12: CARCINOGENESIS Clinical trials invo
Page 13 and 14: CELL CYCLE the RPC contains a two-s
Page 15 and 16: CELL DIVISION Plo1 regulated its af
Page 17 and 18: CELL REGULATION inactivation of ATF
Page 19 and 20: CELL SIGNALLING One probable mechan
Page 21 and 22: CELLULAR AND MOLECULAR PHARMACOLOGY
Page 23 and 24: CLINICAL AND EXPERIMENTAL PHARMACOL
Page 25 and 26: GENE THERAPY ued our studies utilil
Page 27 and 28: IMMUNOLOGY tory cells following tum
Page 29 and 30: MITOTIC SPINDLE FUNCTION & CELL CYC
Page 31 and 32: RADIOCHEMICAL TARGETING AND IMAGING
Page 33 and 34: STEM CELL BIOLOGY their potential w
Page 35 and 36: STEM CELL AND HAEMATOPOIESIS Import
Page 37 and 38: STRUCTURAL CELL BIOLOGY NE disperse
Page 39 and 40: ACADEMIC RADIATION ONCOLOGY: TRANSL
Page 41 and 42: MEDICAL ONCOLOGY: BREAST BIOLOGY me
Page 43 and 44: MEDICAL ONCOLOGY: GENE-IMMUNOTHERAP
Page 45 and 46: MEDICAL ONCOLOGY: GLYCOANGIOGENESIS
Page 47 and 48: MEDICAL ONCOLOGY: PROTEOGLYCAN GROU
Page 49 and 50: CANCER STUDIES: TARGETED THERAPY ne
Page 51 and 52: RESEARCH SERVICES To achieve these
Page 53 and 54: RESEARCH SERVICES The media and pla
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RESEARCH SERVICES successful pilot
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Patents O 6 -Substituted guanine de
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J.L., van Zandwijk, N., Gridelli, C
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Gillies, J.M., Najim, N. and Zweit,
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Clarke, R.B. and Bundred, N.J. (200
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Jayson, G.C., Mulatero, C., Ranson,
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POSTGRADUATE EDUCATION students to
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ADMINISTRATIVE SERVICES The team ha
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Donations to the Institute in 2005
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How to Find Us The Paterson is well
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