Paterson Institute for Cancer Research SCIENTIFIC REPORT 2005

RESEARCH SERVICES
successful pilot studies, this year they have been in
routine use for protein identification, either from
gel spots or from complex LC fractionation, as well
mapping post translational modifications such as
phosphorylation.
The facility has also undertaken a pilot study using
the Isotope Tag Relative Absolute Quantification
(iTRAQ) technique. This project generated relative
quantitation data between two cell lines for several
hundred proteins; in collaboration with the
Bioinformatics Group we then cross mapped these
results with existing microarray data and related the
results to pathway mapping information. The pilot
study has demonstrated the utility of this approach
and we would be happy to support similar projects
in the future.
____________________________________
Kostoris Medical Library
Head: Steve Glover
http://www.christie.nhs.uk/profinfo/departments/lib
rary/default.htm
Collaboration has been the underlying theme of
2005. The announcement regarding the
Manchester Cancer Research Centre should further
formalise the relationship between the Kostoris
Medical Library and the University of Manchester’s
John Rylands Library. Indeed, the last 10 years have
seen the two libraries converging as the product has
moved towards a predominately online environment.
Medical library staff members have acquired university
status as clinical academic support staff
whilst members of the NHS have benefited from
walk-in access to the resources on the main John
Rylands site. The Paterson Institute has also benefited
from this association with access to the academic
network (JANET) enabling the libraries to
provide IP authenticated resources including databases
and online journals. An added post-merger
bonus will be the eligibility of all Paterson Institute
staff to ATHENS authenticated resources such as
BIOSIS, EDINA and MIMAS.
The medical library also has a close collaborative
relationship with the other CR-UK libraries at the
London Research Institute and the Beatson
Institute in Glasgow. In 2005 the library supplied
over 200 documents to scientific staff at the other
CR-UK locations and received 80 for Paterson
staff.
In February 2005 the library was accredited by an
external NHS body under the Health Libraries and
Information Confederation (HELICON) scheme.
The library achieved a Stage 3 accreditation with
areas of significant excellence. 33 out of 36 categories
were awarded an ‘excellent’ level and all 11
must-have criteria were reached. In 2005 the library
also provided the Chair of the Libraries and
Information for Health Network Northwest
(LIHNN), a body that represents over 80 NHS
libraries in Cheshire and Mersey, Cumbria and
Lancashire, and Greater Manchester Strategic
Health Authorities.
2006 will see a move to a more customised Current
Awareness Service (CAS). The CAS service will
combine data mining strategies from the published
literature with the profiled e-toc services aimed at
group level. This enhanced CAS service will maximise
the information opportunities arising from
the Paterson/University merger and give greater
access to published science.
Close up view of the 4000 Q Star showing the electrospray ion source.
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