Paterson Institute for Cancer Research SCIENTIFIC REPORT 2005

56
Publications
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BIOINFORMATICS GROUP (page 8)
Crispin Miller
Refereed Research Papers
Leong, H.S., Yates, T., Wilson, C. and Miller, C.J.
(2005) ADAPT: a database of Affymetrix probesets
and transcripts. Bioinformatics, 21, 2552-2553.
Wilson, C. and Miller, C.J. (2005) Simpleaffy: a
BioConductor package for Affymetrix quality control
and data analysis. Bioinformatics, 21, 3683-3685.
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CARCINOGENESIS GROUP (page 10)
Geoff Margison
Refereed Research Papers
Clemons, M., Kelly, J., Watson, A.J., Howell, A.,
McElhinney, R.S., McMurry, T.B. and Margison,
G.P. (2005) O6-(4-bromothenyl)guanine reverses
temozolomide resistance in human breast tumour
MCF-7 cells and xenografts. Br J Cancer, 93, 1152-
1156.
Geoerger, B., Vassal, G., Doz, F., O’Quigley, J.,
Wartelle, M., Watson, A.J., Raquin, M.A., Frappaz,
D., Chastagner, P., Gentet, J.C., Rubie, H., Couanet,
D., Geoffray, A., Djafari, L., Margison, G.P. and
Pein, F. (2005) Dose finding and O6-alkylguanine- DNA alkyltransferase study of cisplatin combined
with temozolomide in paediatric solid malignancies.
Br J Cancer, 93, 529-537.
Maddineni, S.B., Sangar, V.K., Hendry, J.H.,
Margison, G.P. and Clarke, N.W. (2005) Differential
radiosensitisation by ZD1839 (Iressa), a highly
selective epidermal growth factor receptor tyrosine
kinase inhibitor in two related bladder cancer cell
lines. Br J Cancer, 92, 125-130.
Margison, G.P., Heighway, J., Pearson, S., McGown,
G., Thorncroft, M.R., Watson, A.J., Harrison, K.L.,
Lewis, S.J., Rohde, K., Barber, P.V., O’Donnell, P.,
Povey, A.C. and Santibanez-Koref, M.F. (2005)
Quantitative trait locus analysis reveals two intragenic
sites that influence O6-alkylguanine-DNA alkyltransferase activity in peripheral blood
mononuclear cells. Carcinogenesis, 26, 1473-1480.
Pearson, S.J., Ferguson, J., Santibanez-Koref, M. and
Margison, G.P. (2005) Inhibition of O6-methylgua nine-DNA methyltransferase by an alkyltransferaselike
protein from Escherichia coli. Nucleic Acids Res,
33, 3837-3844.
Plummer, E.R., Middleton, M.R., Jones, C., Olsen,
A., Hickson, I., McHugh, P., Margison, G.P.,
McGown, G., Thorncroft, M., Watson, A.J., Boddy,
A.V., Calvert, A.H., Harris, A.L., Newell, D.R. and
Curtin, N.J. (2005) Temozolomide pharmacodynamics
in patients with metastatic melanoma: DNA
damage and activity of repair enzymes O6-alkylgua nine alkyltransferase and poly(ADP-ribose) polymerase-1.
Clin Cancer Res, 11, 3402-3409.
Saad, A.A., O’Connor, P.J., Mostafa, M.H., Metwalli,
N.E., Cooper, D.P., Povey, A.C. and Margison, G.P.
(2005) Glutathione S-transferase M1, T1 and P1
polymorphisms and bladder cancer risk in
Egyptians. Int J Biol Markers, 20, 69-72.
Schambach, A., Bohne, J., Chandra, S., Will, E.,
Margison, G.P., Williams, D.A. and Baum, C. (2005)
Equal potency of gammaretroviral and lentiviral
SIN vectors for expression of O6-methylguanine- DNA methyltransferase in hematopoietic cells. Mol
Ther, epub Oct 05, printed 2006, 13, 391-400.
Woolford, L.B., Southgate, T.D., Margison, G.P.,
Milsom, M.D. and Fairbairn, L.J. (2005) The P140K
mutant of human O6-methylguanine-DNA-methyl transferase (MGMT) confers resistance in vitro and
in vivo to temozolomide in combination with the
novel MGMT inactivator O6-(4-bromothenyl)gua nine. J Gene Med, epub Aug 05, printed 2006, 8, 29-
34.
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