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Paterson Institute for Cancer Research SCIENTIFIC REPORT 2005

Paterson Institute for Cancer Research SCIENTIFIC REPORT 2005

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5<br />

Contents<br />

Director’s Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6<br />

<strong>Research</strong> Laboratories<br />

Bioin<strong>for</strong>matics Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Crispin Miller..................................................................8<br />

Carcinogenesis Group. . . . . . . . . . . . . . . . . . . . . . . . . . . . . Geoff Margison..........................................................10<br />

Cell Cycle Group. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Karim Labib..................................................................12<br />

Cell Division Group. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Iain Hagan .....................................................................14<br />

Cell Regulation Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . Nic Jones .......................................................................16<br />

Cell Signalling Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Angeliki Malliri ............................................................18<br />

Cellular and Molecular Pharmacology Group . . . . . . . . . Caroline Dive..............................................................20<br />

Clinical and Experimental Pharmacology Group . . . . . . . Caroline Dive and Malcolm Ranson .............22<br />

Gene Therapy Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Lez Fairbairn ................................................................24<br />

Immunology Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Peter L Stern...............................................................26<br />

Mitotic Spindle Function and Cell Cycle Control Group Elmar Schiebel............................................................28<br />

Radiochemical Targeting and Imaging Group . . . . . . . . . . Jamal Zweit ..................................................................30<br />

Stem Cell Biology Group . . . . . . . . . . . . . . . . . . . . . . . . . . Georges Lacaud ........................................................32<br />

Stem Cell and Haematopoiesis Group. . . . . . . . . . . . . . . Valerie Kouskoff.........................................................34<br />

Structural Cell Biology Group . . . . . . . . . . . . . . . . . . . . . . Terence D. Allen........................................................36<br />

University of Manchester Division of <strong>Cancer</strong> Studies<br />

Academic Radiation Oncology Translational<br />

Radiogenomics Group. . . . . . . . . . . . . . . . . . . . . . . . . . . . . Catharine West..........................................................38<br />

Medical Oncology: Breast Biology Group. . . . . . . . . . . . . Rob Clarke...................................................................40<br />

Medical Oncology: Gene Immunotherapy Group . . . . . . Robert Hawkins ........................................................42<br />

Medical Oncology: Glycoangiogenesis Group . . . . . . . . . Gordon Jayson ...........................................................44<br />

Medical Oncology: Proteoglycan Group . . . . . . . . . . . . . . John T Gallagher........................................................46<br />

Targeted Therapy Group. . . . . . . . . . . . . . . . . . . . . . . . . . . Tim Illidge......................................................................48<br />

<strong>Research</strong> Services . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50<br />

Publications. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56<br />

Postgraduate Education . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68<br />

Administrative Services . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70<br />

Acknowledgement <strong>for</strong> Funding of the <strong>Paterson</strong> <strong>Institute</strong>. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72<br />

Career Opportunities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74<br />

How to Find Us . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . inside back cover<br />

P A T E R S O N I N S T I T U T E S C I E N T I F I C R E P O R T 2 0 0 5

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