2005 SAGES Abstracts

POSTER ABSTRACTS
P218–Basic Science
(cellular bio, physiology)
NORMAL INTRA-ABDOMINAL PRESSURE IN HEALTHY
ADULTS William S Cobb MD, Justin M Burns MD, Kent W
Kercher MD, B Todd Heniford MD, Carolinas Medical Center
Purpose: The goal of this study is to measure the normal
range of intra-abdominal pressure in healthy, non-obese adults
and correlate this with sex and body mass index (BMI).
Methods: After Institutional Review Board approval, healthy
young adults with no prior history of abdominal surgery were
enrolled. Intra-abdominal pressure readings were obtained
through a transurethral bladder (Foley) catheter. Each subject
performed 13 different tasks including standing, sitting, bending
at the waist, bending at the knees, performing abdominal
crunches, jumping, climbing stairs, bench pressing 25 pounds,
arm curling 10 pounds, and performing a Valsalva and coughing
both while sitting and standing. Three separate readings
were taken during each maneuver. Data were analyzed by
Student t-test and Pearson’s correlation coefficients
Results: Measurements were taken in 10 male and 10 female
subjects. Mean age of the study group was 22.7 years (range;
18 - 30 years), and BMI averaged 24.6 kg/m2 (range; 18.4 - 31.9
kg/m2). The mean pressures were not different between males
and females for each maneuver. There was a significant correlation
between higher BMI and increased intra-abdominal
pressure in 5 of 13 exercises. The mean maximum pressures
and their correlation coefficients with BMI for these maneuvers
is shown below.
Conclusion: Normal intra-abdominal pressure correlates with
BMI, but does not vary based on sex. The highest intraabdominal
pressures in healthy patients are generated during
coughing and jumping. Patients with higher BMI and chronic
cough appear to generate significant elevation in intra-abdominal
pressure and may potentially be at increased risk for
abdominal wall hernia formation.
P219–Basic Science
(cellular bio, physiology)
CARBON DIOXIDE PNEUMOPERITONEUM POSTTREATMENT
ATTENUATES IL-6 PRODUCTION, Joseph M Fuentes MD, Eric
J Hanly MD,Alexander R Aurora MD,Antonio De Maio
PhD,Michael R Marohn MD,Mark A Talamini MD, Johns
Hopkins University School of Medicine
CO2 pneumoperitoneum is known to have beneficial immune
effects in laparoscopic surgery. We have recently shown that
CO2-pneumoperitoneum posttreatment increases survival. The
purpose of this study was to determine if CO2 pneumoperitoneum
posttreatment would reduce the cytokine response to
lipopolysaccharide (LPS) sepsis. Forty rats (n=10) were randomized
into four groups: CO2 pneumoperitoneum, helium
pneumoperitoneum, anesthesia control, and laparotomy control.
In all groups a laparotomy was performed.
Simultaneously, all animals received intraperitoneal
Escherichia coli LPS (1mg/kg). Immediatley after all animals
were closed, the first three groups received their respective
posttreatment for 30 minutes. Blood samples for serum
cytokine assays were collected via cardiac puncture 2 hours
following LPS injection. Compared to laparotomy/LPS only
control, plasma levels of IL-6 were depressed 54.6% by anesthesia
posttreatment, 77% by He-pneumoperitoneum posttreatment,
and 74.1% by CO2-pneumoperitoneum posttreatment
(*P