Research Report 2000 - MDC

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Patents/Licences The total number of German patents and patent applications from the MDC in 1999 amounted to 98, compared with 86 in 1998 and this included 3 patents which had been awarded before the MDC was established. In 1999, for the first time, the annual number of patent applications reached 20, compared with 19 in 1998. This shows that there is no sign of the innovative ability of MDC researchers reaching a plateau. The first two US patents for discoveries originating from the MDC were awarded in 1999. There were also 12 PCT (Patent Cooperation Treaty) patent applications. In 1999, 3 contract options and 2 licensing contracts were awarded. In addition, the first sale of an MDC patent was concluded. The license income for 1999 amounted to 145,207 DM, compared with 111,711 DM for 1998. This represents a significant year-onyear increase. The MDC has set up a Legal Protection Committee with Dr. Iduna Fichtner, Prof. Walter Birchmeier and Dr. Martin Lipp as members. It is the responsibility of this committee to investigate whether application should be made for foreign patents, in addition to the primary patent protection sought in Germany. This involves the inventors submitting an application to the MDC board and, following a checking procedure by the attorney, Dr. Fritz Baumbach, it is then submitted to the Legal Protection Committee for their consideration. Head: Dr. Fritz Baumbach 144 Technology Transfer The MDC strongly supports all activities concerning the potential commercialization of research results. Therefore, a Technology Transfer Committee headed by Iduna Fichtner has been set up to manage and optimize all activities and improve cooperation among research institutes, small and medium enterprises (SME), and the clinics. In recent years, these activities have led to an increased number of filed and approved patents and this process has been markedly improved by external evaluation of submitted manuscripts for patentable research findings before publication. Activities involving the commercialization of patents have been intensified by direct contact with licensing agencies (e.g. Fraunhofer Patentstelle, British Technology Group). In addition, a Technology Transfer Conference has been held to give scientists the opportunity for direct contact with potential sponsors for their innovations.This conference will be held once a year. Within the MDC, a “Biomedical Research Transfer” initiative has been set up comprising several groups with long-standing and successful experience in applied research. The process of technology transfer will be facilitated by mutual support in grant applications, intensified cooperation and joint presentation of scientific results. Since 1997, six companies have been founded on the campus Berlin-Buch by outsourcing of scientific results from the MDC. Among them are ATUGEN AG, developed by a joint venture with Ribozyme, GenProfile AG, involved in the search for disease-related genes, Kelman GmbH, focussing on the prediction of proteinligand interactions and EPO GmbH, offering support in the development of novel anticancer agents. A joint venture with Schering AG recently led to the foundation of GTB Gene Therapeutics, engaged in the GMP-certified production of viral and nonviral vectors. Head: Dr. Iduna Fichtner Figure 46: Ceremony laying the foundation stone for the second new laboratory building of the BBB’s Biotechnology and Business Development Center for start-up companies on December 17, 1999 with Wolfgang Branoner, Berlin Senator for Economic Affairs (on the left), Detlev Ganten, Scientific Director of the MDC, and Gudrun Erzgräber, Business Director of the BBB Biomedical Research Campus Berlin-Buch GmbH (front row, from left to right).
Press and Public Relations Research at the MDC is conducted at the forefront of biomedical science - in the promising field of molecular medicine. The MDC’s research activities need to be communicated to the general public in a way that can be readily understood. In addition, the MDC’s expenses must be justified to the German tax payer. The Press Department initiated various activities to serve this need which are outlined below. In 1998 and 1999 the MDC Press Department organized more than 30 guided tours for almost 500 visitors - university students, high school students, international delegations, and the general public. These tours included lectures and visits to laboratories of the MDC, the cooperating university affiliated clinics, Robert-Rössle-Cancer-Clinic and Franz Volhard Clinic for Cardiovascular Diseases, and the Hands-on Laboratory at the Biomedical Research Park. In 1998 and 1999 the MDC Press Department also continued the series of popular scientific lectures in the City Hall of Berlin Pankow, initiated in the MDC’s first year of existence, with 18 “Sunday Lectures“ given by scientists from the MDC and other scientific institutions in Germany. It also presented MDC’s research at the Hannover Industrial Fair and at the Berlin Science Fair. A total of 43 news releases published in German and English by the MDC Press Department in 1998 and 1999 were the basis for many reports in the media. About 2 000 newspaper articles with a circulation of well over 230 million copies were published on the MDC, the Robert Rössle Clinic and Franz Volhard Clinic, and the Biomedical Research Park. In addition, 16 television and 16 radio productions, including the BBC Tomorrow’s World and Arte, the French/German program, were aired on the research conducted at the MDC, the clinics and the Biomedical Research Park. In the time-span reported, three press conferences were initiated, organized and moderated by the MDC Press Department. One of these press conferences was held at the “6th International Gene Therapy Symposium” in Berlin-Buch in 1998, the other at the Grand Opening of the Biotechnology Business and Development Center of the BBB Biomedical Research Campus GmbH, also in 1998. The third press conference was initiated to inform about genome research with the American Nobel laureate Paul Berg. He had given a talk in the series of the “Berlin Lectures on Molecular Medicine” in 1999 and had received the Max Delbrück Medal of the MDC and other Berlin research institutions, and the Schering Forschungsgesellschaft at that occasion. In 1998 and 1999 the MDC Press Department prepared and organized more than 160 interviews for the media in Germany and abroad, including newspapers, magazines, television and broadcasting stations and scientific journals such as Nature, Science and The Lancet. It also published four press reports summarizing the coverage of the MDC, the clinics, the Biomedical Research Park, and related topics in the printed press as well as two issues of the MDC-Report, an in-house magazine. Head: Barbara Bachtler Figure 47: The MDC is an international research institute, attracting scientists from all over the world 145
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Research Report 2000 Covers the Per
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Molecular Therapy Molecular and Dev
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The quantum theory, that provided a
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Introduction Clinical Research The
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Genome Research in Berlin- Brandenb
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External Evaluation Over the period
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Congresses In the years reported, t
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Awards A number of prestigious priz
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Genetics, Bioinformatics and Struct
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disorders. Various MDC groups have
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Steen R.G., Kwitek-Black A.E., Glen
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Selected Publications Binas, B., Da
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Technology transfer Based on the fu
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Selected Publications Müller, D.N.
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Selected Publications Hennies, H.C.
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Somatic genetic alterations in brea
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Clinical and Molecular Genetics of
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Selected Publications Toka, H.R., B
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Lbx1, c-met and the control of cell
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Selected Publications Moore, A., Mc
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Selected Publications Herz, J., Wil
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We aim to study the genetic epidemi
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Nucleation Nucleation as a pre-requ
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Selected Publications Damaschun, G.
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Selected Publications Yuan, T., Wal
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stability. By determining the struc
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Role of Protein Dynamics in Enzyme
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Modeling Nucleic Acid Structure and
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Conformation, Stability and Interac
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Protein Structure Analysis and Prot
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Cell Growth and Differentiation 61
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dendritic cells (DC). Adoptive tran
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developmental pathway that may invo
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Regulation of Transcription in Mamm
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Differentiation and Growth Control
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Cell cycle-dependent transcriptiona
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Cell Cycle Regulation Hans-Dieter R
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Epithelial Differentiation, Invasio
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Selected Publications Hartmann, G.,
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Selected Publications Behrens, J.,
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Selected Publications Karsten, U.,
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Depressed contractility in human he
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Understanding calcium handling prot
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VSMCs. We have cloned and character
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Surgical Oncology Peter M. Schlag T
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Ubiquitin System and Endoplasmic Re
Page 93 and 94: P450 Cytochromes and the Endoplasmi
Page 95 and 96: Vascular Biology Hermann Haller Thi
Page 97 and 98: Selected Publications Gollasch, M.,
Page 99 and 100: Electron Microscopy Members of the
Page 101 and 102: Molecular Therapy 101
Page 103 and 104: Hematology, Oncology and Tumor Immu
Page 105 and 106: Selected Publications Sturm, I., K
Page 107 and 108: Selected Publications Westermann, J
Page 109 and 110: fractions. The hematopoietic potent
Page 111 and 112: Interaction of pharmacologically ac
Page 113 and 114: Molecular Basis of Congestive Heart
Page 115 and 116: Selected Publications Schneider, G.
Page 117 and 118: different murine and human tumor ce
Page 119 and 120: Molecular and Cell Biology of Hemat
Page 121 and 122: Phospholipids Dietrich Arndt Cytoto
Page 123 and 124: Regulation and Deregulation of Cell
Page 125 and 126: Evolution, Regulation and Genetic A
Page 127 and 128: Molecular and Developmental Neurosc
Page 129 and 130: Cellular Neurosciences Helmut Kette
Page 131 and 132: Growth Factor and Regeneration Gary
Page 133 and 134: Synapse Formation and Function Fran
Page 135 and 136: Developmental Neurobiology Fritz G.
Page 137 and 138: Selected Publications Volkmer, H.,
Page 139 and 140: Structure and Organization 139
Page 141 and 142: Prof. Dr. Hans Meyer President of t
Page 143: Supporting Divisions Safety The div
Page 147 and 148: Purchasing and Materials Management
Page 149 and 150: Computing The computing group of th
Page 151 and 152: Awards Thomas Biederer Boehringer-M
Page 153 and 154: Index A Abdul, Yetunde 90 Aguirre-A
Page 155 and 156: H Haase, Hannelore 85, 97, 100, 142
Page 157 and 158: Q Qin, Zhihai 107, 117 Quass, Petra
Page 159: Board of Trustees Chair Wolf-Michae
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Research Report 2000 - MDC

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