Research Report 2000 - MDC

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Central Facilities Library The MDC library is a specialized scientific library. Its work involves providing and supplying information in all research areas of the MDC and its associated clinics. The library acts as a modern information centre using advanced network structures and allowing access to information sources around the world. Modern information networks offer the increased possibility of supplying users with specific literature and information resources at their work place. The collection contains more than 40,000 media items and 280 periodicals, many of which are additionally provided in electronic form, and different kinds of non- print materials. Campus-wide provision of major local databases include Medline (starting from 1966 ), Current Contents (5 Science Editions) as well as Science Citation Index with abstracts (starting from 1980) and CD-ROM databases via an internal MDC-network with a range of scientific options. The open area provides 26 reading desks, 5 computer workstations with Internet access. The library operates with the local library computer system SISIS. The OPAC (Online Public Access Catalogue) lists all collections, starting from 1994, and is also available via the internet. Printed catalogues describing older holdings with alphabetical and classified indices are also available while the library and its service are all available via the internet. The client-server architecture provides fast access, regardless of the user’s operating system. The library offers a selection of main links related to research at the campus. Head: Dr. Dorothea Busjahn 148 Animal Facilities Animal experiments make a major contribution to biomedical research, particularly in such complex areas as cardiovascular, cancer and neurological diseases. Animal experiments are especially concerned with the development of methods for improved diagnosis and treatment of human tumors and cardiovascular diseases. They are essential for establishing gene therapy strategies. With the recent development of powerful new technologies for manipulating genes, scientists worldwide have produced thousands of transgenic animals and knock-out models. Both approaches have become invaluable in studies of gene function in disease. In 1993, a transgenic unit was set up to allow the production of transgenic rats and mice and mouse chimeras. Since then, more than 70 transgenic rat strains have been developed to model hypertension. In addition, mice have been reconstructed by ES-cell injection and have been successfully bred since 1995. More than 250 strains of knock-out mice are now available as experimental models in cancer research, as well as cardiovascular and neurological diseases. Of all the research institutes in Berlin, the animal facility of the MDC has the greatest number of genetically engineered rat strains and mice stocks. Four animal houses support transgenic and animal experimentation at the MDC and mice, rats and rabbits are bred. Occupying 1,260 square meters, the facilities include animal rooms (636 m 2 ), operating theatres, storage rooms and cage-washing facilities and animals are bred in a disease-free environment. Nevertheless, the number of available animal rooms and surgical facilities in and around the MDC does not meet present requirements. The rapidly growing number of genetically engineered models of severe human illness means that further animal facilities for breeding and experimentation are needed. The MDC, therefore, plan to construct a new central animal house. The project has been approved by the Board of Trustees and will, hopefully, be opened by the year 2003. Head: Dr. Karin Jacobi Campus Net Management The Campus Net Management of the BBB Biomedical Research Campus Berlin-Buch GmbH is responsible for the operation of the high-speed campus network to supply of campuswide internet server services (mail-, WWW-, FTP-, and phone-servers), and for communication with other networks, e.g. B-WiN (Science Net) and BRAIN (Berlin Research Area Network). Further services for the Campus, like video-conferencing and billing/accounting are under construction. Head: Hans Mitulla Figure 51: The sculpture “Großer Nagelkopf” by the artist Rainer Kriester was exposed on the Berlin-Buch Campus from September 1998 to February 1999 as part of a changing exhibition of sculptures, expressing the link between science and art on the Campus.
Computing The computing group of the MDC manages the central computer facilities of the MDC (Remote Access-, File-, and Backup-servers). The group is responsible for the client/server operation of the MDC’s Administration and Executive Board, and is responsible for the system- and user-support of the SAP-R/3administration system. The group focuses its activities on user-oriented support of data and image processing at the MDC. The group supports users if there are any hardware and software problems, connects PC, Macintosh and local nets with the MDC net, and installs client software for different computer platforms for the usage both the central computer facilities of the MDC and the campus-wide computer facilities of the BBB GmbH. In addition, the group organises standard software courses in our computer laboratory, which is equipped specifically for such purposes. Our computer laboratories for image processing provide support for the research groups if there are any scientific problems involving imageprocessing, data-analysis and - visualisation as well as in the presentation of scientific results (graphics, slides, posters). The latest technology, such as digital photography, video-digitalisation and -processing has been installed. Head: Bernd Lemke Figure 52: Walter Friedrich House, laboratory building of the MDC. The building is named after Walter Friedrich, Head of the Institute of Medicine and Biology of the Academy of Sciences in Berlin-Buch from 1948 to 1960. He was renowned for his contributions with Max von Laue to the electromagnetic nature of X-rays and to X-ray cristallography of proteins and their structure. Technical Affairs During the period covered by this report, the Technical/Works Department has carried out key work associated with the takeover of technical operations for the GMP sector. In conjunction with this, a number of technical safety systems have been installed, functions checked and reflected in the Latest Building Techniques (GLT). In the research buildings of the MDC, airconditioning equipment has been widely installed in the areas that have undergone reconstruction and has now been taken over from the Technical/Works Department. Here, too, the switch to GLT was of particular importance. The telephone equipment of the MDC has been upgraded to a highly sophisticated level and a voice mail system has been added. This now means that the telephone equipment meets ISDN standards. All MDC buildings have been fitted with modern fire alarms and the building are linked to one another and connected to the Berlin Fire Department via a CSN computer. Head: Harry Schenk 149
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Research Report 2000 Covers the Per
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Molecular Therapy Molecular and Dev
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The quantum theory, that provided a
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Introduction Clinical Research The
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Genome Research in Berlin- Brandenb
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External Evaluation Over the period
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Congresses In the years reported, t
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Awards A number of prestigious priz
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Genetics, Bioinformatics and Struct
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disorders. Various MDC groups have
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Steen R.G., Kwitek-Black A.E., Glen
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Selected Publications Binas, B., Da
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Technology transfer Based on the fu
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Selected Publications Müller, D.N.
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Selected Publications Hennies, H.C.
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Somatic genetic alterations in brea
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Clinical and Molecular Genetics of
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Selected Publications Toka, H.R., B
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Lbx1, c-met and the control of cell
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Selected Publications Moore, A., Mc
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Selected Publications Herz, J., Wil
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We aim to study the genetic epidemi
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Nucleation Nucleation as a pre-requ
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Selected Publications Damaschun, G.
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Selected Publications Yuan, T., Wal
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stability. By determining the struc
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Role of Protein Dynamics in Enzyme
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Modeling Nucleic Acid Structure and
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Conformation, Stability and Interac
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Protein Structure Analysis and Prot
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Cell Growth and Differentiation 61
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dendritic cells (DC). Adoptive tran
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developmental pathway that may invo
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Regulation of Transcription in Mamm
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Differentiation and Growth Control
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Cell cycle-dependent transcriptiona
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Cell Cycle Regulation Hans-Dieter R
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Epithelial Differentiation, Invasio
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Selected Publications Hartmann, G.,
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Selected Publications Behrens, J.,
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Selected Publications Karsten, U.,
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Depressed contractility in human he
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Understanding calcium handling prot
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VSMCs. We have cloned and character
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Surgical Oncology Peter M. Schlag T
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Ubiquitin System and Endoplasmic Re
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P450 Cytochromes and the Endoplasmi
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Vascular Biology Hermann Haller Thi
Page 97 and 98: Selected Publications Gollasch, M.,
Page 99 and 100: Electron Microscopy Members of the
Page 101 and 102: Molecular Therapy 101
Page 103 and 104: Hematology, Oncology and Tumor Immu
Page 105 and 106: Selected Publications Sturm, I., K
Page 107 and 108: Selected Publications Westermann, J
Page 109 and 110: fractions. The hematopoietic potent
Page 111 and 112: Interaction of pharmacologically ac
Page 113 and 114: Molecular Basis of Congestive Heart
Page 115 and 116: Selected Publications Schneider, G.
Page 117 and 118: different murine and human tumor ce
Page 119 and 120: Molecular and Cell Biology of Hemat
Page 121 and 122: Phospholipids Dietrich Arndt Cytoto
Page 123 and 124: Regulation and Deregulation of Cell
Page 125 and 126: Evolution, Regulation and Genetic A
Page 127 and 128: Molecular and Developmental Neurosc
Page 129 and 130: Cellular Neurosciences Helmut Kette
Page 131 and 132: Growth Factor and Regeneration Gary
Page 133 and 134: Synapse Formation and Function Fran
Page 135 and 136: Developmental Neurobiology Fritz G.
Page 137 and 138: Selected Publications Volkmer, H.,
Page 139 and 140: Structure and Organization 139
Page 141 and 142: Prof. Dr. Hans Meyer President of t
Page 143 and 144: Supporting Divisions Safety The div
Page 145 and 146: Press and Public Relations Research
Page 147: Purchasing and Materials Management
Page 151 and 152: Awards Thomas Biederer Boehringer-M
Page 153 and 154: Index A Abdul, Yetunde 90 Aguirre-A
Page 155 and 156: H Haase, Hannelore 85, 97, 100, 142
Page 157 and 158: Q Qin, Zhihai 107, 117 Quass, Petra
Page 159: Board of Trustees Chair Wolf-Michae
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