Annual Report 2011 - Center for Advanced Biotechnology and ...

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Publications: Matsuura, I., Chiang, K.-N., Lai, C.-Y., He, D., Wang, G., Ramkumar, R. Uchida, T., Ryo, A., Lu, K. P., and Liu, F. (2010)Pin1 promotes TGF-ß-induced migration and invasion.J. Biol. Chem. 285, 1854-1864. Sasseville, M., Ritter, L. J., Nguyen, T., Liu, F., Mottershead, D. G., Russell, D. L., and Gilchrist, R. B. (2010).Growth differentiation factor 9 signaling requires ERK1/2 activity in mouse granulosa and cumulus cells.J. Cell Sci. 123, 3166-3176. Chang, X., Liu, F., Wang, X., Lin, A., Zhou, H., and Su, B. (2011) The kinases MEKK2 and MEKK3 regulate transforming growth factor-ß-mediated helper T cell differentiation. Immunity 34, 201-212. Liu, F. (2011) Inhibition of Smad3 activity by cyclin D-CDK4 and cyclin E-CDK2 in breast cancer cells. Cell Cycle 10, 186. So, J. Y., Lee, H. J., Smolarek, A. K., Paul, S., Maehr, H., Uskokovic, M., Zheng, X., Conney, A., Cai, L., Liu, F., and Suh, N. (2011) A novel Gemini vitamin D analog represses the expression of a stem cell marker CD44 in breast cancer. Mol. Pharmacol. 79, 360-367. Cohen-Solal K. A., Merrigan K. T., Chan, J. L., Goydos, J. S., Chen, W., Foran, D. J., Liu, F., Lasfar, A., and Reiss, M. (2011) Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-β-mediated growth inhibition. Pigment Cell Melanoma Res. 24, 512-524. Dhar-Mascareno, M., Belishov, I., Liu, F., and Mascareno, E. J. (2011) Hexim-1 modulates androgen receptor and the TGFβ signaling during the progression of prostate cancer. The Prostate in press 21
Dr. Peter Lobel CABM Resident Faculty Member Professor Department of Pharmacology UMDNJ-Robert Wood Johnson Medical School Dr. David Sleat Research Associate Professor Dr. Haiyan Zheng Principal Research Associate Dr. Yu Meng Research Associate Dr. Istvan Sohar Research Associate Ling Huang Graduate Student Su Xu Graduate Fellow Mukarram El-Banna Research Teaching Spec. Dr. Meiqian Qian Research Teaching Spec. Protein Targeting Laboratory Dr. Peter Lobel trained at Columbia University and Washington University in St. Louis and joined CABM in 1989. He is currently conducting research on lysosomes and associated human hereditary metabolic diseases. This work resulted in identification of three disease genes that cause fatal neurodegenerative disorders. He was a Searle Scholar and received the excellence in research award from the UMDNJ Foundation. Dr. Lobel is the director of the CABM Mass Spectrometry Core Facility. . Our laboratory has developed new methods for disease discovery that evolved from our research on lysosomal enzyme targeting. Lysosomes are membrane-bound, acidic organelles that are found in all eukaryotic cells. They contain a variety of different proteases, glycosidases, lipases, phosphatases, nucleases and other hydrolytic enzymes, most of which are delivered to the lysosome by the mannose 6phosphate targeting system. In this pathway, lysosomal enzymes are recognized as different from other glycoproteins and are selectively phosphorylated on mannose residues. The mannose 6-phosphate serves as a recognition marker that allows the enzymes to bind mannose 6-phosphate receptor which ferries the lysosomal enzyme to the lysosome. In the lysosome, the enzymes function in concert to break down complex biological macromolecules into simple components. The importance of these enzymes is underscored by the identification of over thirty lysosomal storage disorders (e.g., Tay Sach's disease) where loss of a single lysosomal enzyme leads to severe health problems including neurodegeneration, progressive mental retardation and early death. Our approach to identify the molecular basis for unsolved lysosomal storage disorders is based on our ability to use mannose 6-phosphate receptor derivatives to visualize and purify mannose 6-phosphate containing lysosomal enzymes. Once we discover the cause of a given disease, we conduct further research to understand the underlying system and potentially to develop therapeutics. We also investigate the basic mechanism for targeting of lysosomal proteins and the composition of the lysosome. 22
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CABM RETREAT, June 30, 2011 Cook Ca
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25 th Anniversary CABM Symposium Fr
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Edery Lab Joseph Albistur George Gh
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PATENTS P. Lobel, et al. “Methods
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Montelione, G.T., Ma, L. and Krug,
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Outside Academic Members Dr. Wayne
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Former CABM Scientific Advisory Boa
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Fiscal Information 86
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Anderson, Stephen Rutgers CABM Gran
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Leukemia & Lymphoma Society BFL-1 a
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Total Award Start - End FY 2011 Dir
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Department of Defense Tumor suppres
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