Annual Report 2011 - Center for Advanced Biotechnology and ...

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Cell & Developmental Biology Laboratory Faculty Director Molecular Chronobiology Isaac Edery 8 Tumor Virology Céline Gélinas 11 Bacterial Physiology and Protein Engineering Masayori Inouye 15 Growth and Differentiation Control Fang Liu 19 Protein Targeting Peter Lobel 22 Developmental Neurogenetics James Millonig 25 Viral Pathogenesis Arnold Rabson 29 Molecular Virology Aaron Shatkin 32 Molecular Neurodevelopment Mengqing Xiang 35 7
Dr. Isaac Edery CABM Resident Faculty Member Professor Department of Molecular Biology and Biochemistry Rutgers University Dr. Rudra Dubey Asst. Research Professor Dr. Weihuan Cao Research Assistant Dr. Kwang Huei Low Research Assistant Evrim Yildirim Graduate Student Chhaya Dharia Lab Researcher Molecular Chronobiology Laboratory Dr. Isaac Edery completed his doctoral studies in biochemistry as a Royal Canadian Cancer Research Fellow under Dr. Nahum Sonenberg at McGill University in Montreal. His Ph.D. research focused on the role of the eukaryotic mRNA cap structure during protein synthesis and precursor mRNA splicing. Subsequently, he was in the laboratory of Dr. Michael Rosbash at Brandeis University where he pursued postdoctoral studies aimed at understanding the time-keeping mechanism underlying circadian clocks. He joined CABM in 1993, and his research is supported by NIH. Dr. Edery is a member of the editorial board of Chronobiology International and Journal of Biological Rhythms. The main focus of the Edery lab is to understand the biochemical and cellular bases underlying circadian (~24 hr) rhythms, using Drosophila as a model system. Our strength lies in applying biochemical strategies that are integrated with genetic, ecological and evolutionary perspectives to understand how circadian clocks function and regulate animal physiology and behavior. Circadian rhythms are driven by cellular clocks and enable organisms to anticipate daily and seasonal changes in environmental conditions, ensuring activities occur at optimal times in the day and appropriate seasonal responses are elicited. Understanding how clocks function is highly relevant for human health and well-being. Indeed, clock malfunctions in humans have been implicated in many diseases, including manic-depression, cancer, sleep problems and metabolic syndromes. Our lab is investigating the core clock mechanism, identifying novel clock proteins and how they interact to build a biological time-keeping device that is synchronized to local time. In a second major effort, we are determining the role of clocks in seasonal adaptation, which has led to novel ecological and evolutionary implications. These studies have also broadened our research scope by revealing mechanisms that regulate sleep and arousal. In addition, we are investigating how environmental stimuli, most notably temperature, controls global gene expression. Below is a brief summary of some of our ongoing research and future directions Mechanisms underlying circadian clocks: The central clock mechanism is a dynamically changing multi-subunit biochemical oscillator based on a small set of interacting core “clock” proteins and auxiliary factors that as a unit generates a selfperpetuating daily transcriptional feedback loop that also drives global cyclical gene expression, which underlies many of the daily rhythms manifested by organisms. In addition, to the transcriptional architecture, numerous post-translational regulatory pathways, most notably reversible phosphorylation, regulate various aspects of clock 8
Page 1: CENTER FOR ADVANCED BIOTECHNOLOGY A
Page 4 and 5: Director’s Overview CABM—25 and
Page 6 and 7: of Health, National Science Foundat
Page 10 and 11: protein metabolism/activity, such t
Page 12 and 13: Dr. Céline Gélinas CABM Resident
Page 14 and 15: (CHINJ, CINJ and CABM) and Lauri Go
Page 16 and 17: Dr. Masayori Inouye CABM Resident F
Page 18 and 19: Xu, Z., Mirochnitchenko, O., Xu, C.
Page 20 and 21: Dr. Fang Liu CABM Resident Faculty
Page 22 and 23: Publications: Matsuura, I., Chiang,
Page 24 and 25: In the prior year, we have made con
Page 26 and 27: Dr. James Millonig CABM Resident Fa
Page 28 and 29: We have mapped 5 different vl modif
Page 30 and 31: Dr. Arnold Rabson Director Child He
Page 32 and 33: Publications: Zheng, X., Cui, X.X.,
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Page 36 and 37: Dr. Mengqing Xiang CABM Resident Fa
Page 38 and 39: neurons diminish while there is a s
Page 40 and 41: Laboratory Faculty Director Structu
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Page 48 and 49: Dr. Helen M. Berman Board of Govern
Page 50 and 51: Dr. Chenghua Shao Research Associat
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Page 54 and 55: The long-term goals of our studies
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Zhao, L., Zhao, K., Hurst, R., Slat
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Acton, T.B., Xiao, R., Anderson, S.
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Kryshtafovych, A., Bartual, S.G., B
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properties by lowering susceptibili
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Dr. Ann M. Stock Associate Director
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Publications: Barbieri, C.M., Mack,
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Lectures and Seminars 69
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CABM RETREAT, June 30, 2011 Cook Ca
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25 th Anniversary CABM Symposium Fr
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Edery Lab Joseph Albistur George Gh
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PATENTS P. Lobel, et al. “Methods
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Montelione, G.T., Ma, L. and Krug,
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Outside Academic Members Dr. Wayne
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Former CABM Scientific Advisory Boa
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Fiscal Information 86
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Anderson, Stephen Rutgers CABM Gran
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Leukemia & Lymphoma Society BFL-1 a
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Total Award Start - End FY 2011 Dir
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Department of Defense Tumor suppres
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Total Award Start - End FY 2011 Dir
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