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Annual Report 2011 - Center for Advanced Biotechnology and ...

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Dr. Helen M. Berman<br />

Board of Governors Professor<br />

Department of Chemistry <strong>and</strong><br />

Chemical Biology<br />

Interim Director<br />

Biological, Mathematical, <strong>and</strong><br />

Physical Sciences Interfaces<br />

(BioMaPS),<br />

Director<br />

RCSB Protein Data Bank<br />

Director<br />

PSI Structural Biology<br />

Knowledgebase<br />

Rutgers University<br />

Dr. Martha Quesada<br />

Research Professor<br />

Dr. John Westbrook<br />

Research Professor<br />

Dr. Feng Zukang<br />

Research Professor<br />

Dr. Catherine Lawson<br />

Associate Research Professor<br />

Dr. Shuchismita Dutta<br />

Assistant Research Professor<br />

Dr. Monica Sekharan<br />

Assistant Research Professor<br />

Dr. Jasmine Young<br />

Assistant Research Professor<br />

Structural Biology <strong>and</strong> Bioin<strong>for</strong>matics<br />

Dr. Berman's research area is structural biology <strong>and</strong> bioin<strong>for</strong>matics, with a<br />

special focus on protein-nucleic acid interactions. She is the founder of the<br />

Nucleic Acid Database, a repository of in<strong>for</strong>mation about the structures of<br />

nucleic acid-containing molecules; <strong>and</strong> is the co-founder <strong>and</strong> Director of the<br />

Protein Data Bank, the international repository of the structures of biological<br />

macromolecules. Professor Berman also leads the Protein Structure Initiative<br />

Structural Biology Knowledgebase. She is a Fellow of the American<br />

Association <strong>for</strong> the Advancement of Science <strong>and</strong> of the Biophysical Society,<br />

from which she received the Distinguished Service Award in 2000. A past<br />

president of the American Crystallographic Association, she is a recipient of<br />

the Buerger Award (2006) <strong>and</strong> a member of the inaugural class of ACA<br />

Fellows (<strong>2011</strong>). Dr. Berman received her A.B. in 1964 from Barnard College<br />

<strong>and</strong> a Ph.D. in 1967 from the University of Pittsburgh. She received the<br />

Department of Chemistry Alumni Award from the University of Pittsburgh in<br />

2010.<br />

The Protein Data Bank<br />

The Research Collaboratory <strong>for</strong> Structural Bioin<strong>for</strong>matics (RCSB) Protein Data Bank<br />

(PDB) supports scientific research <strong>and</strong> education worldwide by providing an essential<br />

resource of in<strong>for</strong>mation about biomolecular structures.<br />

The PDB archive is the single repository of in<strong>for</strong>mation about the 3D structures of<br />

large biological molecules, primarily proteins <strong>and</strong> nucleic acids. Scientists from<br />

around the world submit their data about their experiments to the PDB, which is then<br />

processed <strong>and</strong> made freely available in the PDB archive. The RCSB PDB, which is<br />

based at Rutgers <strong>and</strong> the University of Cali<strong>for</strong>nia, San Diego, manages the PDB<br />

archive as a member of the Worldwide PDB (wwPDB).<br />

The wwPDB organization (www.wwpdb.org) was <strong>for</strong>med to ensure that the PDB<br />

archive is <strong>and</strong> will be freely <strong>and</strong> publicly available to the global community. The<br />

wwPDB members (RCSB PDB, Protein Data Bank in Europe (PDBe), Protein Data<br />

Bank Japan (PDBj), <strong>and</strong> the BioMagResBank (BMRB)) host deposition, processing,<br />

<strong>and</strong> distribution centers <strong>for</strong> PDB data <strong>and</strong> collaborate on a variety of projects <strong>and</strong><br />

outreach ef<strong>for</strong>ts. As 'archive keeper' <strong>for</strong> the wwPDB, the RCSB PDB maintains the<br />

central repository of the PDB archive.<br />

The central activity of the wwPDB is the collection, validation, archiving <strong>and</strong><br />

distribution of high quality structural data to the scientific community on a timely<br />

basis. The systems developed by the RCSB PDB are reliable <strong>and</strong> stable to meet the<br />

challenges of high data rates <strong>and</strong> complex structures. As of November 8, <strong>2011</strong>, the<br />

PDB archive contains more than 77,000 entries.<br />

47

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