Annual Report 2011 - Center for Advanced Biotechnology and ...

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Lazarus, R.A., Hurle, M., Anderson, S. and Powers, D.B. "Enzymes for the production of 2-keto-L-gulonic acid". U. S. Patent No. 5,912,161 Arnold, E., Kenyon, G.L., Stauber, M., Maurer, K., Eargle, D., Muscate, A., Leavitt, A., Roe, D.C., Ewing, T.J.A., Skillman, A.G., Jr., Kuntz, I.D. and Young, M. “Naphthols useful in antiviral methods”. U.S. Patent No. 6,140,368 Arnold, E. and Ferstandig Arnold, G. "Chimeric Rhinoviruses". U.S. Patent No. 5,714,374 Krupey, J., Smith, A., Arnold, E. and Donnelly, R. "Method of Adsorbing Viruses from Fluid Compositions". U.S. Patent No. 5,658,779 Arnold, E. and Ferstandig Arnold, G. "Chimeric Rhinoviruses". U.S. Patent No. 5,541,100 Edery, I., Altman, M. and Sonenberg, N. “Isolation of full-length cDNA clones and capped mRNA”. U.S. Patent No. 5219989 Lobel, P. and Sleat, D. "Human lysosomal protein and methods of its use". US Patent No. 6,302,685 B1 Lobel, P. and Sleat, D., “Human lysosomal protein and methods of its use”. US Patent No. 6,638,712. Submitted 10/28/2003 Millonig, J.H., Brzustowicz, L,M. and Gharani, N. “Genes as diagnostic tools for autism”. Provisional application submitted 7/1/03 Montelione, G.T., Anderson, S. and Huang, Y. “Linking gene sequence to gene function by 3D protein structure determination”. EU Patent 99935746.0-2402. Issued in United Kingdom Stein, S. and Montelione, G.T. “Site specific 13C-enriched reagents for magnetic resonance imaging”. U.S. Patent No. 6210655 Montelione, G. T. and Krug, R. “Process for designing inhibitors of influenza virus non-structural protein 1”. Filed November 13, 2003. PCT/US03/36292. Patent Pending. Montelione, G.T., Krug, R., Yin, C. and Ma, L. “Novel compositions and vaccines against influenza A and influenza B infections”. Filed November 17, 2006. Patent Pending. Montelione, G. T, Arnold, E., Das, K., Ma, L., Xiao, R., Twu, K.Y., Rei-Lin, K. and Krug, R.M. “Influenza A virus vaccines and inhibitors”. Filed January 23, 2007. Patent Pending. Montelione, G.T., Das, K. and Arnold, E. “Ribosomal RNA methyltransferases RlmAI and RlmAII: Drug target validation and process for developing an inhibitor assay”. Submitted June 26, 2004; Priority date: June 27, 2003. PTC/US2004/020244. Patent Pending. 79
Montelione, G.T., Ma, L. and Krug, R.M. “An assay for designing small molecule inhibitors of the life cycle of influenza (Flu) virus targeted to the viral non-structural protein 1”. Provisional Patent Application submitted March 2007. Suzuki, M., Schneider, W., Tang, Y., Roth, M., Inouye, M. and Montelione, G.T. “Processes using E. coli single protein production system (SPP) for deuterium/methyl enrichment of proteins, detergent screening of membrane proteins using NMR, and peptide bond labeling for high throughput NMR assignments”. Provisional Patent Application submitted March 2007. Xiao, R.; Nie, Y.; Xu, Y.; Montelione, G.T. “Three NADPH-dependant stereospecific reductase from Candida parapsilosis and their application to chiral alcohol production.” Provisional Patent Application submitted June 2009. Shatkin, A.J., Pillutla, R., Reinberg, D., Maldonado, E. and Yue, Z. “mRNA Capping enzymes and uses thereof.” U.S. Patent No. 631292631. 80
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CENTER FOR ADVANCED BIOTECHNOLOGY A
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Director’s Overview CABM—25 and
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of Health, National Science Foundat
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Cell & Developmental Biology Labora
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protein metabolism/activity, such t
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Dr. Céline Gélinas CABM Resident
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(CHINJ, CINJ and CABM) and Lauri Go
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Dr. Masayori Inouye CABM Resident F
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Xu, Z., Mirochnitchenko, O., Xu, C.
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Dr. Fang Liu CABM Resident Faculty
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Publications: Matsuura, I., Chiang,
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In the prior year, we have made con
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Dr. James Millonig CABM Resident Fa
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We have mapped 5 different vl modif
Page 30 and 31: Dr. Arnold Rabson Director Child He
Page 32 and 33: Publications: Zheng, X., Cui, X.X.,
Page 34 and 35: polymerase II, facilitating the sel
Page 36 and 37: Dr. Mengqing Xiang CABM Resident Fa
Page 38 and 39: neurons diminish while there is a s
Page 40 and 41: Laboratory Faculty Director Structu
Page 42 and 43: Human transcription factors are typ
Page 44 and 45: atomic detail and have yielded nume
Page 46 and 47: Figure from Das et al., 2011 showin
Page 48 and 49: Dr. Helen M. Berman Board of Govern
Page 50 and 51: Dr. Chenghua Shao Research Associat
Page 52 and 53: Dr. Joseph Marcotrigiano CABM Resid
Page 54 and 55: The long-term goals of our studies
Page 56 and 57: s Publications: Singarapu, K.K., Mi
Page 58 and 59: Zhao, L., Zhao, K., Hurst, R., Slat
Page 60 and 61: Acton, T.B., Xiao, R., Anderson, S.
Page 62 and 63: Kryshtafovych, A., Bartual, S.G., B
Page 64 and 65: properties by lowering susceptibili
Page 66 and 67: Dr. Ann M. Stock Associate Director
Page 68 and 69: Publications: Barbieri, C.M., Mack,
Page 70 and 71: Lectures and Seminars 69
Page 72 and 73: CABM RETREAT, June 30, 2011 Cook Ca
Page 75 and 76: 25 th Anniversary CABM Symposium Fr
Page 77 and 78: Edery Lab Joseph Albistur George Gh
Page 79: PATENTS P. Lobel, et al. “Methods
Page 83 and 84: Outside Academic Members Dr. Wayne
Page 85 and 86: Former CABM Scientific Advisory Boa
Page 87 and 88: Fiscal Information 86
Page 89 and 90: Anderson, Stephen Rutgers CABM Gran
Page 91 and 92: Leukemia & Lymphoma Society BFL-1 a
Page 93 and 94: Total Award Start - End FY 2011 Dir
Page 95 and 96: Department of Defense Tumor suppres
Page 97 and 98: Total Award Start - End FY 2011 Dir
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