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Nutrigenomics- Nutritional Research with a MolecuBy LisbethMunksgaard,Director,Centre forAdvancedFood Studies,Denmark(lm@lmc.dk)Mapping of the human genome hasmade it possible to study the influenceof diet on which genes are upordown-regulated. Genes code forproteins, which again regulate orcatalyze the formation of metabolites,which may change in abundancedepending on gene expressionrates. Studying the effect of dieton the system of genes, proteinsand metabolites is called “nutrigenomics”.Nutrigenomics is a new, promisingtool in nutritional science. Themolecular approach aims to revealprecise, biochemical explanations tonutritional mechanisms. This mayhelp us to change the regime of increasingobesity and related life stylediseases. Research in nutrigenomicsis a priority in the collaboration betweenpublic, Danish food and nutritionresearch and the private foodsector.Applications of nutrigenomicsWhile health is an increasingly importantdeterminant for choice offoods in some consumer segments,unhealthy eating and drinking habitsremain the cause of bad healthand large economic losses for society.The market for well-documented,healthy foods that meet the modernconsumer’s demands for convenienceis increasing world-wide.However, the proper documentationof improved health effects of foodsis currently a major obstacle for innovationworldwide. Nutrigenomicscan serve a systematic approach tothe revealing new biomarkers and atool to improve throughput in foodtesting and health claim documentation.Such a standard will meet thelegal requirement according to a recentlyproposed EU regulation.Functional foods are developedto improve health, well-being andto have other functions such as improveddigestion. The internationalmarket has seen many pre-and probioticproducts, especially related todigestion. Nutrigenomics serves agreat potential for obtaining betterinformation regarding their interactionwith the gut flora and theireffects in the individual. This informationwill strengthen knowledgebaseddevelopment of cultures forhealth improved food and feed andfor targeted choice of ingredients,variety of vegetables or breed of animalsfor production of food with improvedhealthiness.Nutrigenomics may:● lead to tools that can prove healthclaims● give basis for development of functionalfoods or ingredients thatmay improve healthiness of food● lead to more precise nutritional adviceto individuals and to groups ofindividuals (elderly people, top athletes)and food specifically addressedto people with specific needs.The regime of genes, proteins and metabolites creates a huge number of data. Bioinformatics is statistical handling of the data inorder to identify differences between samples.20 Danish Dairy & Food Industry... worldwide 2006NR. 16
lar ApproachCentre for Advanced Food StudiesAll major Danish food science institutionsin Denmark (see box) collaboratewithin the frame of Centrefor Advanced Food Studies (LMC).LMC coordinates the scientific activitiesand higher educations withinthe food area and serves as a uniquepartner for the private and publicfood sector. LMC was establishedin 1992, highly encouraged by theprivate Danish food sector. LMC is acentre of excellence within food science.Groups in the LMC frame areinvolved in more than 40 projectsunder EU Frame Work 6 program andhave the leading role in a number ofprojects.LMCLMC is an interdisciplinary collaboration of research and education withinfood science and technology. The following institutions take part in LMC:The Royal Veterinary and Agricultural University (www.kvl.dk)Technical University of Denmark (www.dtu.dk)Danish Institute of Agricultural Sciences (www.agrsci.dk)MAPP-centre, Aarhus School of Business (www.asb.dk)Danish Institute for Food and Veterinary Research (www.dfvf.dk)Danish Institute for Fisheries Research (www.dfu.min.dk)University of Southern Denmark (www.sdu.dk)Please visit our website at www.lmc.dk for more information on LMC.Nutrigenomics is a priority in theLMC strategy 2006-10. A new, internationalM. Sc. programme willstart in September 2006. A nationalresearch platform is headed by ProfessorLars Ove Dragsted, Danish Veterinaryand Food Research. The institutionscooperating within LMC houseworld leading groups within omicstechniques, bioinformatics (ProfessorSøren Brunak at the TechnicalUniversity of Denmark) and humanintervention studies and obesity (ProfessorArne Astrup, the Royal Veterinaryand Agricultural University).LMC hosted an international nutrigenomicsconference in March2006. After the conference LMC andGenome Canada hosted a workshopfor selected scientists from Denmarkand Canada and invited keynotespeakers from US and Holland. ■opus FIL-D-01GEA MEMBRANE FILTRATIONIndustry Know-How– Process ExpertiseFrom ingredient production tobacterial removal – GEA Filtrationbrings know-how and industryunderstanding to any partnership.GEA Filtration is a world leader incrossflow membrane filtration,with reverse osmosis and nano-,ultra-, and microfiltration ascore technologies.A company of mg technologies groupGEA FiltrationGEA Filtration • Noerskovvej 1b • DK-8660 Skanderborg • DenmarkTel: +45 70 15 22 00 • Fax: +45 70 15 22 44 • info@geafiltration.dk • www.geafiltration.comNR. 16Danish Dairy & Food Industry... worldwide 2006 21
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