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ORAL ABSTRACTS - SATURDAY, 23 MAY 2015identify the causes as precisely as possible with a special focus on sudden cardiac deaths andarrests, and therefore, to improve screening and preventive measures.Methods: The registry is a confidential web-based database and conducted by the Institute of Sportsand Preventive Medicine in Saarbruecken, Germany. The database records cases of sudden deathand sudden cardiac arrest (including cases of sudden cardiac arrest which the patient survives)occurring during or within one hour after sporting activity.Results: So far, sudden deaths in football were registered in 23 cases. The mean age of the 22 maleplayers and one female player was 27 ± 11 years. 20 players deceased from a sudden cardiac death,3 suffered from a lethal traumatic injury. 15 deaths happened during the match, 2 during the warmup, 1 after the match, and 5 during training. 4 sudden cardiac arrests could be resuscitated (2myocardial infarctions, 1 coronary anomaly, 1 unknown underlying disease). Compared to theGerman sudden cardiac death registry the international cases of sudden deaths during football wereyounger (22 ± 5 vs. 35 ± 15 years).Conclusion: Although sudden deaths during football seem to be rare, these preliminary data supporta pre competition medical assessment due to the young age of deceased players, as a main reasonfor sudden cardiac deaths under the age of 35 years are congenital heart diseases.S46.4Strenuous exercise and endothelial function in professional soccer playersNikolaos Androulakis(1), N Koundourakis(1), M Marketou(2), P Spatharaki(3), E Nioti(3), JChristoforakis (1), M Alexandrakis(3)(1) Ergotelis F.C. Medical Team, Iraklion Crete, Greece(2) Department of Cardiology, Iraklion University Hospital, Iraklion, Greece(3) Hematology laboratory, Iraklion University Hospital, Iraklion, GreeceObjectives: To examine whether strenuous exercise can lead to endothelial activation and/ordysfunction in professional soccer players due to exercise induced oxidative stress.Methods: Twenty-three (15 non-smokers and 8 smokers) healthy, elite male professional soccerplayers (mean Age: 25.2±4.3 years, BMI: 23.1±1.3 kg/m2, Fat: 7.8±2.6%), were selected for thisstudy. All participants had a full clinical and laboratory evaluation. Von Willebrand factor antigenvWf Ag) plasma levels were measured on two different occasions: one day before the beginning ofthe preseason preparation period and after 7 weeks of strenuous exercise.Results: Analysis revealed a significant decrease in vWf Ag plasma levels among the non-smokers,at the end of the experimental period (p=0.018, 95% CI), suggesting a potential beneficial effect onthe endothelium of these athletes. Furthermore, multivariate analysis showed that the combinationof age >29 years and smoking can significantly impair this effect (p=0,033).Conclusions: Strenuous exercise did not lead to endothelium activation or dysfunction on welltrainednon-smoking soccer players. On the contrary, it seemed to produce a beneficial effect on theendothelium of these players. This beneficial effect was moderated by the combination of age > 29years and smoking.180