Small Business AdministrationprogramsGovernment funding to fuel thestate’s biomedical industry alsocomes from the U.S. Small BusinessAdministration’s (SBA) Office ofTechnology. The SBA’s two grantprograms were implemented to increasethe competitiveness of small, hightechnologyfirms.The first, the Small Business InnovationResearch (SBIR) program, providescritical seed capital for biomedicalentrepreneurs and occasionally providesinitial funding for startup companies.Under the SBIR program, federaldepartments and agencies with annualextramural R&D budgets exceeding$100 million must reserve at least 2.5percent of those budgets for awards tosmall U.S. high-tech firms.The second program — the SmallBusiness Technology Transfer (STTR)— reserves 0.30 percent of the funds offederal departments and agencies withannual extramural research budgetsexceeding $1 billion for awards to smallU.S. high-tech firms. These awards aresmaller than the SBIR grants and fundcooperative R&D projects involvingsmall business and a nonprofit researchinstitution.The SBIR and STTR dollars remaincritical for the development of newbiomedical products, especially in thecurrent economic climate. <strong>California</strong>companies have been successful inobtaining the highly competitiveawards, and, in 2009 again took thelargest share of the grants. <strong>California</strong>entities received SBIR and STTR awardstotaling more than $117 million. Thattotal amounted to 27.1 percent of thecollective funds received by the top 10recipient states.Figure 31: 52: Top Top 10 10 recipients recipients of NIH of NIH SBIR SBIR and STTR and STTR Funds ($M) Funds, 2009 ($M)<strong>California</strong>MassachusettsNew YorkMarylandNorth CarolinaPennsylvaniaWashingtonOhioColoradoTexas$20.5$19.3$25.4$24.2$32.2$29.8$38.0$44.1$81.4Source: National <strong>Institute</strong>s of Health, Office of Extramural ResearchNote: Data excludes R&D contracts and projects funded by the American Recovery and Reinvestment Act.American Recovery and Reinvestment Act funding<strong>California</strong> also was a significant beneficiary of the American Recovery andReinvestment Act (ARRA) grants, many of which were administered through theNIH. Figures 53 and 54 below show the totals and the state’s percentage of thosegrant programs.Figure 53: NIH grants funded by the American Recovery and Reinvestment Actof 2009Recovery ActProjects(FY 2009)Funding(FY 2009)Recovery ActProjects(FY 2010)$117.0Funding(FY 2010)<strong>California</strong> 1,706 $636,616,123 1,217 $689,513,934Share of National Grants 13.3% 14.6% 13.9% 14.9%Figure 54: NIH grants funded by the American Recovery and ReinvestmentAct of 2009 - Top 10 recipients by funding in FY 2009Recovery Act Projects (FY 2009) Funding (FY 2009)<strong>California</strong> 1,706 $636,616,123Massachusetts 1,237 $501,767,963New York 1,142 $379,928,579Pennsylvania 812 $278,484,448Texas 670 $213,074,281North Carolina 558 $192,847,747Maryland 478 $172,663,253Washington 388 $170,069,481Illinois 505 $143,930,276Michigan 394 $129,423,91070 | <strong>California</strong> <strong>Biomedical</strong> <strong>Industry</strong> 2011 Report
<strong>California</strong> NIH Funded Research and InnovationUniversity of <strong>California</strong>Partnering with NIH to advance medical science and improve healthcareUC: An economic engineand innovator in <strong>California</strong>• UC research has been essentialto the development of many of<strong>California</strong>’s leading industries—from biotechnology to informationtechnology to telecommunications.• Nearly 400,000 jobs in <strong>California</strong>depend on UC operations. Thatincludes non-university jobs thatuniversity expenditures create.• UC contributes more than $14billion in <strong>California</strong> economicactivity and more than $4 billion instate and local tax revenues eachyear.• More than 1,000 <strong>California</strong> biotech,high-tech and other innovativeR&D-intensive companies put UCresearch to work every day.• One-third of <strong>California</strong>’s biotechfirms were founded by UCscientists, and one-fourth ofbiotech firms in the U.S. are within35 miles of a UC campus.• UC researchers produce, onaverage, four new inventions a day,and UC develops more patentsthan any other university in thenation.William Tucker, executive director ofInnovation Alliances and Services atthe UC Office of the President, states,“NIH’s commitment to basic life scienceresearch at universities over the past30 years, combined with the ability ofuniversities to patent and license relatedinventions, has resulted in the U.S.creating and leading the biotechnologyindustry. We are pleased that theObama administration has publiclyrecognized the importance of, and isactively looking for ways to enhancethe impact of federally-funded researchon the nation’s technology-drivenbusiness sectors, such as the biomedicalindustry.”UC researchers garnered more than$1.95 billion in NIH funding in 2009-10, accounting for 43 percent of UC’stotal research budget. UC sciencetouches our daily lives, allowingphysicians to identify medicalconditions early and provide hope forsignificant medical challenges.They include:••Artificial lung surfactant, whichallows premature infants to breathe••Herceptin to treat breast cancer••The nicotine patch for smokingcessation••A catheter to treat aneurysms••A chochlear implant to help the deafunderstand normal speech••Hepatitis B vaccine••MRI and PET technology to detectdiseaseIn addition to these advances, UChas untangled the building blocksof many complicated diseases, fromAIDS and Alzheimer’s to cancer andcardiovascular conditions.Among important discoveries by NIHfundedUC researchers:••Proto-oncogenes, or normal genesthat have the potential to convertto cancer genes. The discoverytransformed the way that scientistslook at cancer and is leading tonew strategies for detection andtreatment.••The prion, an infectiouspathogen that causes certain fatalneurodegenerative diseases, such asbovine spongiform encephalopathy,commonly known as mad-cowdisease. This discovery could provideinsights into the prevention ofAlzheimer’s disease.••Telomerase, an enzyme that playsa key role in normal cell function.The discovery provides a new targetfor treating age-related diseases andcancer and for measuring the impactof stress on cells.••Insight into HIV. UC researcherswere the first to identify and describeHIV, a watershed discovery in AIDSresearch.Funding from NIH also supports thelocal and regional economy that it fuelsvia the patents and scientific advancesthe research generates and the relatedindustries, such as biotechnology.Top five products based on UCtechnology by revenue for FY2009($M)Hepatitis-B vaccine $15.909Treatment of intracranial aneurysms $11.427Interstitial cystitis therapy $8.723EGF receptor antibodies $5.947Bovine growth hormone $5.488UC inventionsInventiondisclosuresU.S.patentsissuedTotal UCU.S. patentportfolio2005 1,304 310 3,2752006 1,308 270 3,3162007 1,411 331 3,4252008 1,497 224 3,5462009 1,482 244 3,617Start-up companies formed with UCtechnologiesNumber of UC start-ups2005 232006 422007 412008 482009 47Overall, 461 start-up companieshave been formed with UC campusinventions since 1976.<strong>California</strong> <strong>Biomedical</strong> <strong>Industry</strong> 2011 Report | 71