Demenciák diagnózisa és kezelése

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Kísérő tünetek lehetnek:személyiségváltozás,agitáció,gátlástalanságapátia,pszichózis,alvászavar,Parkinsonizmus,(DLB,CBD,PSP,MSA-c,p,a,FTD,VD)epilepszia,delírium
– Recurrent seizures in patients with dementia: Frequency, seizure types,and treatment outcome.– Rao SC, Dove G, Cascino GD, Petersen RC.– Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.– OBJECTIVE: Patients with a primary neurodegenerative disorder associated withcognitive impairment are at increased risk for epilepsy. The goal of the presentstudy was to characterize seizure type(s), etiological diagnosis of dementia,electroencephalogram (EEG) and imaging findings, and response to antiepilepticdrug (AED) therapy in these individuals. METHODS: A retrospective study wasperformed identifying patients in the Mayo Alzheimer Disease Patient Registry(ADPR) and Alzheimer Disease Research Center (ADRC) who were classified ashaving dementia and epilepsy from 1986 to 2006. Multiple clinical parameterswere extracted from patient charts and evaluated to characterize the primaryneurodegenerative disorder and seizure outcomes. RESULTS: Sixty-three three of the1738 ADPR and ADRC patients (3.6%) had epilepsy. . Twenty-four of the 63patients were excluded because of insufficient information regarding theirepilepsy. The remaining 39 patients were analyzed. Twenty-eight eight of the 63patients (72%) experienced complex partial seizures. . Head MRI wasperformed in 35 patients (90%). Fourteen patients (36%) had MRI-identifiedstructural lesions that included remote stroke and prior intracerebral hemorrhage.EEGs were obtained in 29 patients (74%). Fifteen patients (38%) hadepileptiform discharges. Overall, it was found that 79% had an excellentresponse to AED therapy. Approximately one-third of the patients had dose-related side effects from an AED. CONCLUSION: The present study indicatedthat most individuals with the comorbidity of epilepsy and dementia havecomplex partial seizures that may be adequately controlled on AED therapy.The long-term effect of seizure activity on the neurodegenerative disorder isunknown.
Page 1 and 2: Demenciák diagnózisa és kezelés
Page 3 and 4: - Alzheimer 50-70 %- Vascularis: al
Page 5: A demenciák diagnosztikus ismérve
Page 9 and 10: A demencia-szindrómák osztályoz
Page 12 and 13: Corticalis és subcorticalis demenc
Page 14 and 15: A demenciák diagnosztikája 2.Klin
Page 16 and 17: A demenciák diagnosztikája 4.1. N
Page 18 and 19: A leggyakoribb primer demenciákdif
Page 20 and 21: A demenciák kórok szerintiosztál
Page 22 and 23: Az Alzheimer kór1901. A. Alzheimer
Page 24 and 25: 1.2.3.4.Az Alzheimer demencia fázi
Page 26 and 27: Az Alzheimer-kór kockázati ténye
Page 28 and 29: Genetikai rizikófaktorokKorai AD (
Page 30: Triggerek:- Genetikai mutációk- R
Page 33 and 34: AchEI:Az AD kezelési lehetőségei
Page 35 and 36: Lancet Neurol. 2008 Jul;7(7):575.La
Page 37 and 38: Nem csak gyógyszer!A demens beteg
Page 39 and 40: 1892 PickPick betegség- Tau tartal
Page 41 and 42: VDStroke után 25-30 %Bal oldali in
Page 43 and 44: VD diagnózisaHachinski Ischemic sc
Page 45: Differential Diagnosis of DementiaV

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