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GHB45a coma-like state for which paramedics are needed to resuscitatethe victim. Other effects of high doses of GHB include visualhallucinations, delusions, out-of-body experiences, vertigo (dizziness),disorientation, depression, and amnesia. Respiration isseverely decreased at these higher doses, with reports of breathingrates as low as 6–10 breaths per minute. High doses of GHB canalso cause one to lose control of the bladder or bowels. Othereffects that are experienced at high doses include nausea andvomiting, seizures, respiratory arrest, coma, and even death, especiallywhen GHB is mixed with other drugs like methamphetamine.All of these effects can have a quick onset, and unlike drinkingalcoholic beverages, once the user starts to feel these effects, he orshe is unable to “slow down” to avoid any further complications.The effects of GHB are strongly enhanced, and muchmore dangerous, when it is used in combination with alcohol.Thus, the likelihood of the user experiencing one of GHB’smore severe effects (such as seizure, coma, or death) is greatlyincreased when it is combined with alcohol. In fact, morethan 80% of all GHB-related deaths involve the combineduse of GHB and alcohol. GHB overdoses can also result from“boosting” (taking another dose before the effects of the firstdose wear off). Since 1990, the Drug Enforcement Agencyhas documented more than 70 deaths that were related toGHB overdoses.As mentioned earlier, raw GHB powder is often mixed withother chemicals, including those found in engine degreasers andfloor strippers. With repeated GHB use, these chemicals canerode the lining of the user’s mouth and esophagus.HOW GHB WORKS IN THE BRAINSurprisingly, GHB is naturally present in most cells of thehuman body at very low concentrations. Although the functionof the body’s own GHB is not clear, scientists believe it maybe involved with cellular metabolism. GHB is also found in thebrain and is believed to act as a neurotransmitter. It is believed