Microsoft PowerPoint - src.ppt [\310\243\310\257 \270\360\265\345]
Microsoft PowerPoint - src.ppt [\310\243\310\257 \270\360\265\345]
Microsoft PowerPoint - src.ppt [\310\243\310\257 \270\360\265\345]
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Glucotoxicity, Lipotoxicity,Glucolipotocicity• Adverse or toxic influence on pancreatic β cellfunction caused by excessive glucose and/orlipids• Glucotoxicity (1985, Unger RH et al, Diabetologia)• Lipotoxicity (1995, Unger RH, Diabetes)• Glucolipotoxicity (2002, Prentki M et al, Diabetes)- lipotoxicity is dependent on glucose levels