Microsoft PowerPoint - src.ppt [\310\243\310\257 \270\360\265\345]

More documents

Recommendations

Info

$Microsoft PowerPoint - S14-1_\300\374\274\272\277\317 [\310\243 ...$

$Microsoft PowerPoint - S7-1_\300\374\277\353\260\374$

$Microsoft PowerPoint - src.ppt [\310\243\310\257 \270\360\265\345]$

$(Microsoft PowerPoint - WDXKRSAWSXRU.ppt [\310\243\310\257 ...$

• Antioxidant enzymes :Superoxide dismutase, Catalase, Glutathione Peroxidase• Heat Shock Proteins :HSP 70Heme Oxygenase-1
• Complementary action of antioxidant enzymes in the protection ofbioengineered insulin-producing RINm5F cells against the toxicity ofreactive oxygen species. (Tiedge M et al Diabetes 47:1578-1585, 1998)• Protection against the co-operative toxicity of nitric oxide and oxygenfree radicals by overexpression of antioxidant enzymes inbioengineered insulin-producing RINm5F cells.(Tiedge M et al Diabetologia 42:849-855, 1999)• Stable expression of manganese superoxide dismutase in insulinomacells prevents IL-1beta-induced cytotoxicity and reduces nitric oxideproduction. (Hohmeier HE et al J Clin Invest 101:1811-1820, 1998)• Contribution of adenoviral-mediated superoxide dismutase genetransfer to the reduction in nitric oxide-induced cytotoxicity on humanislets and INS-1 insulin-secreting cells.(Moriscot C et al Diabetologia 43:625-631, 2000)
Page 1 and 2: β cell and Hyperglycemia in Type 2
Page 3 and 4: Schema of five stages of progressio
Page 5: GlucotoxicityChronic exposure to hi
Page 8 and 9: The glucotoxic effect on insulin ge
Page 10 and 11: 1.5†‡Insulin/ b-actin mRNA1.00.
Page 12 and 13: Chronic exposure to high glucose co
Page 15 and 16: γ GCS m RNAGSH level (µmol/mg)444
Page 17 and 18: mesothelial cellsleukocytesGSH leve
Page 19 and 20: γ -GCS Expression : Summary & Conc
Page 21 and 22: Effects of glucose on lipid partiti
Page 23 and 24: (McGarry JD Diabetes 51: 7-18, 2002
Page 25 and 26: Oxidative stressAdaptiveresponseEPO
Page 27 and 28: Control MetforminLeptin (ug) 0 0.1
Page 29 and 30: Lipotoxicity in Human Pancreatic Is
Page 31 and 32: Metformin in β cells• To evaluat
Page 33 and 34: 100Metformin 25 µg/mlFluorescence
Page 35 and 36: Metformin : Summary & Conclusion•
Page 37: Des-fluoro-sitagliptin (DFS):11-Wee
Page 41 and 42: (A)122 Kd80 Kd(B)51 KdDensity (% Co
Page 43 and 44: Protective effect of Heme Oxygenase
Page 45 and 46: HO-1 mRNAβ-actin mRNAAfter HO-1 ad
Page 47 and 48: Lipotoxicity and Type 2 Diabetes
Page 49 and 50: FFAs in the pathogenesisof type 2 d
Page 51 and 52: Glucotoxicity vs. LipotoxicityGluco
Page 53 and 54: Consequences of treating ZDF rats w
Page 55 and 56: IntestinalLumenLipaseACAT: Acyl Co-
Page 57 and 58: High glucose levels increase choles
Page 59 and 60: FAT/CD36*ㅜㅜ ㅜ* p
Page 61 and 62: • At only lipotoxic condition (5.
Page 63 and 64: Summary
Page 65 and 66: • In human studies of type 2 diab
Page 67: 감사합니다

Microsoft PowerPoint - src.ppt [\310\243\310\257 \270\360\265\345]

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?