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• Metformin restores insulin secretion altered by chronicexposure to free fatty acid or high glucose(Patane G et al. Diabetes 49:753-740,2000)• Activation of the AMP-activated protein kinase by the antidiabeticdrug metformin in vivo(Zou MH et al. J Biol Chem 279:43940-43951,2004)•Metformin, but not leptin, regulated AMP-activated proteinkinase in pancreatic islets: impact on GSIS(Leclerec I et al. Am J Physiol Endocrinol 286:1023-1032,2004)