Microsoft PowerPoint - src.ppt [\310\243\310\257 \270\360\265\345]
Microsoft PowerPoint - src.ppt [\310\243\310\257 \270\360\265\345]
Microsoft PowerPoint - src.ppt [\310\243\310\257 \270\360\265\345]
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Metformin↓ ACC activityPhosphorylation/activation of AMPK↓ SREBP-1 expression↓ SREBP-1 activity↓ Hepatic gene expression : FAS,L-PK,S14↑ Muscle glucose transport?↓ Hepatic FA, VLDL synthesis(↑hepatic FA oxidation)↓ Hepatic glucose production↓ Hapatic steatosis↑ Liver insulin sensitivity↓ Plasma glucose, triglyceride, FFAModel for the mechanism by which metformin mediates effects on lipid and glucose metabolism