Microsoft PowerPoint - src.ppt [\310\243\310\257 \270\360\265\345]

• There are ample evidences at the cellular level1) Glucotoxicity & oxidative stress : Glucose form ROS2) Pancreatic islets contain an usually low complement of antioxidantproteins and activity but normal γ -GCS expression3) Antioxidant drugs improve pancreatic islet survival in the face ofoxidative stress4) Gene transfer techniques can be used to overexpress antioxidantenzymes or HO-1 which provide enhanced protection of pancreaticbeta cells against oxidative stress5) At islets exposed to high glucose, high fatty acid may beexacerbating β cell dysfunction via increasing of CD 366) Because hyperglycemia is a prerequisite for lipotoxicity to occure,the term glucolipotoxicity, rather than lipotoxicity, is moreappropriate