Microsoft PowerPoint - src.ppt [\310\243\310\257 \270\360\265\345]
Microsoft PowerPoint - src.ppt [\310\243\310\257 \270\360\265\345]
Microsoft PowerPoint - src.ppt [\310\243\310\257 \270\360\265\345]
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Lipotoxicity• Acquired cause of impaired β-cell function• Short term exposure of islets to FFA- stimulates insulin secretion- LCFA Fatty acyl CoA DAG PKC Exocytosis• Long term exposure of islets to FFA- inhibit insulin secretion- through Randle cycle(McGarry JD Diabetes 51: 7-18, 2002)