Microsoft PowerPoint - src.ppt [\310\243\310\257 \270\360\265\345]

Oxidative stressAdaptiveresponseEPO generepressionActivation of antioxidantdefensesRepression of ROSproducingsystemsTF activation(e.g. AP-1, NF-χB, Nrf2)Immediate-early geneinduction (e.g. c-fos)TF inhibitionSpecific decrease in(e.g. NFI) RNA stabilityInduction of antioxidant genes:Glutathione peroxidaseCatalaseSODγ-GlutamylcysteinesynthaseGlutathione reductaseThioredoxinThioredoxin reductaseQuinone reductaseMetallothioneinHeme oxygenaseFerritin ...+Activation of several other genes (e.g. cytokines)CYP1A1repressionMitochondrialactivityshutdown+TransferrinreceptordecreaseNADPHoxidaseinhibition(Y Morel et al Biochem J 342:481-496,1999)