FTD Respiratory pathogens 21 plus - Mikrogen

18.3 Clinical evaluation
FTD Respiratory pathogens 21 plus version 5/ March 2012 english
FTD Respiratory pathogens 21 plus
All clinical samples were tested with existing multiplex PCRs and the FTD Resp
21plus. Except For the detection of HKU and Cpneu there was no reference PCR
available.
233 nasopharyngeal and pleural effusion samples were analyzed. The following
statistic shows how many positives of each pathogen had been detected (table
10).
The results for the reference PCR and the new FTD Resp21plus PCR were nearly
comparable. On one hand new pathogens (HKU, Cpneu) were not detectable
with the older FTD assay and on the other hand EV and PV were not dividable in
the old FTD Resp+ test.
Table 10: Statistical analysis of the clinical evaluation data for the FTD Resp 21 plus in
comparison with the older version FTD Resp plus. * 1 - No older reference PCR available in FTD;
x* 2 - EV and PV are dividable in the new FTD Resp 21 test ; na - not analyzable
Pathogen
...
Reference
method
FTD Resp21plus
pos neg
pos a c
neg b d
- 30 -
Total
...
Sensitivity
(%)
Specificity
(%)
a/(a+c) x 100 d/(d+b) x 100