Global Programme to Eliminate Lymphatic Filariasis ... - libdoc.who.int

148Annual Report on Lymphatic Filariasis 2003ANNEXES Annex 4 Abbreviations and definitionsDEFINITIONSserious adverse experienceAn event that is fatal, life-threatening, disabling, or incapacitating or that results in hospitalization, prolongs a hospitalstay, or is associated with congenital abnormality, cancer or overdose (either accidental or intentional); any experiencethat the investigator regards as serious or that would suggest any significant hazard, contraindication, side-effect,or precaution that may be associated with the use of the drug should be reported as a serious event.Case classificationlymphatic filariasis caseAn individual currently infected with Brugia malayi, B. timori or Wuchereria bancrofti, whether or not microfilaraemic.clinical caseAn individual with any of the clinical findings of hydrocele, chylocele, lymphoedema, chyluria, haematochyluria, haematuria,hypereosinophilia, or tropical pulmonary eosinophilia syndrome, for which other causes have been excluded in aresident of, or long-term visitor to, an endemic area, plus specific antibody elevations in visitors to endemic regions.probable caseA case that meets the clinical case definition.confirmed caseA case confirmed by laboratory or ultrasound examinations. Laboratory criteria for diagnosis of infection are presenceof microfilariae or circulating filarial antigen or detection of adult worm(s) by ultrasound or biopsy.EndemicityA country is classified into:implementation unit (IU) for MDAA designated administrative area in a country; if the area is identified as endemic or having indigenous transmission,the entire population should be treated with recommended antifilarial (AF) drugs.endemic IUAn IU or any population area (e.g. village or urban area) with an LF infection rate of 1% or more among its nativepopulation.endemicA country with any IUs known or reported to be endemic since 1980.never endemicA country with no history or evidence of endemic filariasis.post-endemicA country with a known history of endemic filariasis before 1980, but with no evidence of transmission or new infectionsince 1980.uncertainA country with a history of endemic filariasis before 1980 or with evidence of infection in immigrants but no clearevidence of indigenous transmission.