NDRI Quinquennium Book COVER FINAL CURVE.cdr

TheQuinquennium Golden2007-2012(SIB-ESA) has the potential for its commercial applicationfor routine monitoring of milk for Aflatoxin M1 under Indiancondition of milk production and processing.Microbiological interventions for improvedhuman health...••Putative probiotic strains of Indigenous lactobacilliviz.Lp21, Lp43, Lp55, Lp57, Lp9, Lp91 and CH4demonstrated strong antioxidative properties andsignificantly up regulated the expression of SOD2, GPx-1and CAT genes in HT-29 cells in vitro and hence can beexplored as novel antioxidants to protect the host againstoxidative stress induced diseases.••The indigenous probiotic lactobacillus strain Lf1 exhibiteda protective role in DSS induced colitis in mice based onimprovement in DAI, histological scores, decrease in MDAlevels and increase in the expression of SOD2and TrxR-I.••Another potential indigenous probiotic lactobacillus strainLp91 exhibited strong immuno-modulatory propertiesunder in vivo conditions in mice colitis model••Lp91 significantly reduced the plasma total cholesterol,LDL-cholesterol and triglycerides by 18, 27 and 27% in SDrats fed on high cholesterol diet through the mediation ofBsh activity••Two of the putative indigenous Lactobacillus strains Lp9and Lp91 not only survived at acidic pH and high bile saltconcentrations, but also possessed strong hydrophobicityand adherence property to support their effectivecolonization in the gut.••Lp9 and Lp91 also boosted the immune response bymodulating the expression of pro- and anti-inflammatorycytokines, mucin barrier function along with othersignaling molecules in HT-29 cells under different sets ofexperimental conditions.21