D7 - Uro,Endocrine

CASE REPORT• presents to hospital with palpitations,intolerance of heat, increased appetite• physical exam: exophthalmos, moistskin, pulse 110, diffusely enlargedthyroid glanddiagnosis?• labs – thyroid function testdiagnostic methods??• Graves disease• low TSH and high T3 and T4• scintigraphy – diffuse uptake of radioactive iodine• TSH-R antibodies presentPathology of endocrine systemThyroid gland goiterGraves - Basedow disease (70)- autoimmune disease (TSH-R stimulating Ab)- hyperthyroidism- hyperplasia of folicullar cells forming papillary projections into the lumen- depletion of colloid („moth-eaten“)1 cmGraves - Basedow diseaseprojections into the lumen of the thyroid folliclesprojections into the follicle lumen and scalloped colloid at the periphery adjacent to the follicular cellsGraves - Basedow disease (70)Graves - Basedow disease (70)10