D7 - Uro,Endocrine

EM – physiological glomerulus , REM – podocytes pediclesE – Endothelium, BM – Basal membrane, P- Podocyte, FP – Pedicles of the podocytesMesangial cellsPathology of uropoetic systemGlomerulonephritis (59,61)• renal disease characterized by inflammation of the glomeruli• cause – antibodies, IK (circulating, local formation)• acute / rapidly progressive / chronic• clinical presentation:- nephritic syndrome (hypertension, oedema, oliguria, hematuria)- nephrotic syndrome (proteinuria, hypoalb., hyperlip., lipiduria,oedema)- combinationWhite arrow – subendothelial, Black arrow – subepithelial deposistsPathology of uropoetic systemGlomerulonephritis – morphological changesImmunofluoresence positivityMinimal change GN- no changes on light microscopy- on electron microscopy fusion of podocytes- nephrotic syndromeFocal Segmental Glomerulosclerosis (FSGS)- only some glomeruli within the kidney are affected and only aparts of a glomerulus- sclerosis of glomeruli and hyalinisation of arterioles- steroids are often not effective, often ending in renal failureMembranous glomerulonephritis- subepithel. "spike" deposits → thickening of BM- without cell proliferation2