D7 - Uro,Endocrine

Pathology of uropoetic systemTuRenal cell carcinoma (53)• Grawitz tumor, malignant, 80% renal tumors in adults• hematuria, flank and vague pain, palpable abdominal mass (in lessthan 10% of patients), paraneoplastic syndromes (EPO production)• multilobulated tumor, yellow-orange color, focal hemorrhage andnecrosis• clear cytoplasma cells – glycogen a lipidskidneyRenal cell carcinomaTu – neoplastic cells with abundant clear cytoplasmkidney tissueRenal cell carcinoma Renal cell carcinoma (53)Pathology of uropoetic systemundifferentiaited mesenchymal tissueNephroblastoma (Wilms’ tumor) (251)• most common solid tumor in young children (usually age before 4years)• chr 11 (WT1,2)• histologically 3 elements:- metanephric blastema- immature spindled cell stroma (muscle, cartilage, bone, fattissue, fibrous tissue)- immature epithelial elements (abortive tubules and glomeruli)undifferentiaited blastemaNephroblastoma (Wilms’ tumor) (251)7