D7 - Uro,Endocrine

More documents

Recommendations

Info

EM – physiological glomerulus , REM – podocytes pediclesE – Endothelium, BM – Basal membrane, P- Podocyte, FP – Pedicles of the podocytesMesangial cellsPathology of uropoetic systemGlomerulonephritis (59,61)• renal disease characterized by inflammation of the glomeruli• cause – antibodies, IK (circulating, local formation)• acute / rapidly progressive / chronic• clinical presentation:- nephritic syndrome (hypertension, oedema, oliguria, hematuria)- nephrotic syndrome (proteinuria, hypoalb., hyperlip., lipiduria,oedema)- combinationWhite arrow – subendothelial, Black arrow – subepithelial deposistsPathology of uropoetic systemGlomerulonephritis – morphological changesImmunofluoresence positivityMinimal change GN- no changes on light microscopy- on electron microscopy fusion of podocytes- nephrotic syndromeFocal Segmental Glomerulosclerosis (FSGS)- only some glomeruli within the kidney are affected and only aparts of a glomerulus- sclerosis of glomeruli and hyalinisation of arterioles- steroids are often not effective, often ending in renal failureMembranous glomerulonephritis- subepithel. "spike" deposits → thickening of BM- without cell proliferation2
thickening of glomerular capillaries /wire loops/Membranous glomerulonephritisMembranous glomerulonephritisthickening of glomerular capillaries /wire loops/Membranous glomerulonephritis (“spikes“)Pathology of uropoetic systemGlomerulonephritis – morphological changesProliferativeMesangial proliferative GN- IgA nephropathy (Berger's disease) – most common GN in adults- increased number of mesangial cells and matrix- IgA deposits in mesangium- macroscopic haematuriaEndocapillary GN- post-infectious (10-14d after streptococcal infection – group A β-hemolytic)- enlarged glomeruli, proliferating endothelial and mesangial cells +PMNL, Mo- nephritic syndromeMesangiocapillary (membranoproliferative) GN- proliferation of mesangial cells, matrix and thickening of capillariesglomerulus with prolifrating mesangila cellstubulsMesangial proliferative glomerulonephritisMembranoproliferative glomerulonephritis /IgG deposits/3
Page 1: 1-2PATHOLOGY OF UROPOETIC AND ENDOC
Page 5 and 6: CASE REPORTCASE REPORT25-year-old w
Page 7 and 8: Pathology of uropoetic systemTuRena
Page 9 and 10: Pathology of endocrine systemThyroi
Page 11 and 12: Pathology of endocrine systemadrena

D7 - Uro,Endocrine

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?