D7 - Uro,Endocrine

Wilms Tu – immature tubules and glomeruliPathology of endocine systemDiabetes mellitus= metabolic disorder characterised by hyperglycemia due to substantiallyreduced or nonexists insulin secretion1.) Type I DM (total insuline deficiency)2.) Type II DM (relative insuline deficiency)3.) Other types of DM4.) Gestational DMNephroblastoma (Wilms’ tumor) (251)Complications:- acute: diabeticketoacidosis, nonketotichyperosmolar coma, hypoglycemia- chronic: macroangiopathy,microangiopathy (diabetic retinopathy,nefropathy), diabetic neuropathy, diabeticfootPathology of endocine systemDiabeticic nephropathy (159)- increase in mesangial matrix → glomerulosclerosis- diffuse- nodular (Kimmelstiel(Kimmelstiel-Wilsonsyndrome)- sclerosis of small arteries- Armani cells – prox. tubular cells filled glykogencalcificateGlomerulosclerosis and arteriolosclerosis (159)Glomerulosclerosis – hyalinisation (159) Glomerulosclerosis – Kimmelstiel Wilson disease (159)8