D7 - Uro,Endocrine

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Wilms Tu – immature tubules and glomeruliPathology of endocine systemDiabetes mellitus= metabolic disorder characterised by hyperglycemia due to substantiallyreduced or nonexists insulin secretion1.) Type I DM (total insuline deficiency)2.) Type II DM (relative insuline deficiency)3.) Other types of DM4.) Gestational DMNephroblastoma (Wilms’ tumor) (251)Complications:- acute: diabeticketoacidosis, nonketotichyperosmolar coma, hypoglycemia- chronic: macroangiopathy,microangiopathy (diabetic retinopathy,nefropathy), diabetic neuropathy, diabeticfootPathology of endocine systemDiabeticic nephropathy (159)- increase in mesangial matrix → glomerulosclerosis- diffuse- nodular (Kimmelstiel(Kimmelstiel-Wilsonsyndrome)- sclerosis of small arteries- Armani cells – prox. tubular cells filled glykogencalcificateGlomerulosclerosis and arteriolosclerosis (159)Glomerulosclerosis – hyalinisation (159) Glomerulosclerosis – Kimmelstiel Wilson disease (159)8
Pathology of endocrine systemThyroid gland goiterHashimoto’s disease (tyreoiditis) (240)- chronic lymphocytic tyreoiditis- lymphocytic infiltrate and follicles, oncocytes- autoimmune disease (TSH-R blocking Ab, other Ab, T-cells)- hypothyroidismHashimoto’s diseaselymphocytic infiltrate and lymphatic follicles with germinal centers replacing gland tissuelymphatic follicles with germinal centersHashimoto’s disease (240)Hashimoto’s disease (240)lymphatic follicle with germinal centerCASE REPORT35-year-old womanthyroid folliclesHashimoto’s disease (240)9
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D7 - Uro,Endocrine

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