D7 - Uro,Endocrine

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enal pelvisinfiltrate of neutrophils in tubuli and renal interstitiumuretherAcute tubointerstitial nephritisAcute tubointerstitial nephritis (94)CASE REPORTabsces60-year-old manAcute tubointerstitial nephritis (94)CASE REPORT• presents to hospitel with dark-coloredurine and flank pain• history: low grade fever, lost 10kg in 3months, chronic smoker?diagnosis?diagnostic methods?• labs - polycythemia, urinanalysis - hematuria• USG, CT – 3x4cm mass on left kidney• biopsy• renal cell carcinoma6
Pathology of uropoetic systemTuRenal cell carcinoma (53)• Grawitz tumor, malignant, 80% renal tumors in adults• hematuria, flank and vague pain, palpable abdominal mass (in lessthan 10% of patients), paraneoplastic syndromes (EPO production)• multilobulated tumor, yellow-orange color, focal hemorrhage andnecrosis• clear cytoplasma cells – glycogen a lipidskidneyRenal cell carcinomaTu – neoplastic cells with abundant clear cytoplasmkidney tissueRenal cell carcinoma Renal cell carcinoma (53)Pathology of uropoetic systemundifferentiaited mesenchymal tissueNephroblastoma (Wilms’ tumor) (251)• most common solid tumor in young children (usually age before 4years)• chr 11 (WT1,2)• histologically 3 elements:- metanephric blastema- immature spindled cell stroma (muscle, cartilage, bone, fattissue, fibrous tissue)- immature epithelial elements (abortive tubules and glomeruli)undifferentiaited blastemaNephroblastoma (Wilms’ tumor) (251)7
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D7 - Uro,Endocrine

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