MDR Bacterial Infections Our Treatment Option

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Population PharmacokineticAnalysis of CMS & Colistin afterIV Administration in Critically IllPatientsNormal renal functionPlachouras D, Karvanen M, Friberg LE, et al. Populationpharmacokinetic analysis of colistin methanesulfonate andcolistin after intravenous administration in critically illpatients with infections caused by gram-negative bacteria.Antimicrob Agents Chemother 2009;53:3430–6
Model-predicted CMS & Colistin Concentrations inCritically Ill PatientsCurrent dosing regimen of CMS in a typical patient1. 3 MU (240 mg of CMS)2. A 15-min infusion3. every 8 hours [q8h])Alternative dosing regimens with1. Loading doses of1.1 9 MU CMS (720 mg. of CMS)1.2 or 12 MU CMS (960 mg of CMS)2. Duration of infusions2.1 15 min2.2 or 2 h3. A maintenance dose of• 4.5 MU (360 mg) CMS• Every 12 h (q12h)Plachouras D, Karvanen M, Friberg LE, et al. Population pharmacokinetic analysis of colistin methanesulfonate and colistin after intravenous administration incritically ill patients with infections caused by gram-negative bacteria. Antimicrob Agents Chemother 2009;53:3430–6
Page 1 and 2: MDR Bacterial Infections:Our Treatm
Page 5 and 6: IDSA News: 10 New Antibiotics by 20
Page 7 and 8: 60504030201001911102010719992000261
Page 9 and 10: Definition & Action of KPC, CRKP an
Page 11 and 12: Maria Souli, Irene Galani, Anastasi
Page 13 and 14: Antimicrobial Susceptibility for ND
Page 15 and 16: KPC-p K. pneumoniaeisolate. (USA)Ca
Page 18 and 19: MIC distributions of NDM-1 Enteroba
Page 20 and 21: Drug of Choice for ESBL-producingEn
Page 22 and 23: Antimicrobial Option by Risk Level
Page 24 and 25: In vitro activities of fosfomycin a
Page 26 and 27: 0.5, 1.0, 2.0-gm Human Simulated Pr
Page 28 and 29: FIC Index & InterpretationInterpret
Page 30 and 31: FIC Index of MDR P. aeruginosaStrai
Page 34 and 35: Attenuation of Colistin Bactericida
Page 36 and 37: Pharmacokinetic/Pharmacodynamic Det
Page 38 and 39: Recommended Definite Therapy for Se
Page 40 and 41: Breakpoint Criteria of Vancomycin f
Page 42 and 43: One Gram bid: Enough for Vancomycin
Page 44 and 45: การใชยา vancomycin
Page 46 and 47: ยาขนานอื่น ถ
Page 48 and 49: Early Combination Rx vs. Monotherap
Page 54: Thank youAny Comment?Any Question?

MDR Bacterial Infections Our Treatment Option

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