MDR Bacterial Infections Our Treatment Option

Pharmacokinetic/Pharmacodynamic Determinant of ColistinActivity against Pseudomonas aeruginosaThe fAUC/MIC targetsRequired to achieve kill against the three strains1-log kill 2-log killNeutropenic rat model- The thigh infection model 15.6 - 22.8 27.6 - 36.1- The lung infection model 12.2 - 16.7 36.9 - 45.9This in vivo study indicated the importance of achieving adequatetime-averaged exposure to colistinThe results will facilitate efforts to define more rational design ofdosage regimens in humans.Dudhani RV, Turnidge JD, Coulthard K, Milne RW, Rayner CR, Li J, Nation RL. Elucidation of pharmacokinetic/pharmacodynamic determinant ofcolistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models. Antimicrob Agents Chemother 2010;54(3):1117-24