MDR Bacterial Infections Our Treatment Option

Early Combination Rx vs. Monotherapyin Septic ShockA total of 4,662 eligible cases of culture-positive, bacterialseptic shock treated with combination or monotherapy fromwhich 1223 propensity-matched pairs were generated.The primary outcome of study was 28-day mortality.Using a Cox proportional hazards model,Combination Rx MonoRx• 28-day mortality 355/1223 (29%) 444/1223 (36.3%)• Hazard ratio 0.77• 95% CI 0.67-0.88 (p = 0.0002)Kumar A, Zarychanski R, Light B, Parrillo J, Maki D, Simon D, Laporta D, et al. Early combination antibiotic therapy yields improvedsurvival compared with monotherapy in septic shock: a propensity-matched analysis. Crit Care Med 2010;38:1773-85.